Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Morouço, P.; Fernandes, C.; Lattanzi, W.

Publication

Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

2021-02-27Journal article

dc.contributor.author	Morouço, P.
dc.contributor.author	Fernandes, C.
dc.contributor.author	Lattanzi, W.
dc.date.accessioned	2023-03-17T18:58:20Z
dc.date.available	2023-03-17T18:58:20Z
dc.date.issued	2021-02-27
dc.description.abstract	Due to the extremely high incidence of lesions and diseases in aging population, it is critical to put all efforts into developing a successful implant for osteochondral tissue regeneration. Many of the patients undergoing surgery present osteochondral fissure extending until the subchondral bone (corresponding to a IV grade according to the conventional radiographic classification by Berndt and Harty). Therefore, strategies for functional tissue regeneration should also aim at healing the subchondral bone and joint interface, besides hyaline cartilage. With the ambition of contributing to solving this problem, several research groups have been working intensively on the development of tailored implants that could promote that complex osteochondral regeneration. These implants may be manufactured through a wide variety of processes and use a wide variety of (bio)materials. This review aimed to examine the state of the art regarding the challenges, advantages, and drawbacks of the current strategies for osteochondral regeneration. One of the most promising approaches relies on the principles of additive manufacturing, where technologies are used that allow for the production of complex 3D structures with a high level of control, intended and predefined geometry, size, and interconnected pores, in a reproducible way. However, not all materials are suitable for these processes, and their features should be examined, targeting a successful regeneration.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Morouço, P.; Fernandes, C.; Lattanzi, W. Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies. J. Funct. Biomater. 2021, 12, 17. https://doi.org/10.3390/jfb12010017	pt_PT
dc.identifier.doi	10.3390/jfb12010017	pt_PT
dc.identifier.issn	2079-4983
dc.identifier.uri	http://hdl.handle.net/10400.8/8253
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	MDPI	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Additive manufacturing	pt_PT
dc.subject	Biomaterials	pt_PT
dc.subject	Regenerative medicine	pt_PT
dc.subject	Tissue engineering	pt_PT
dc.subject	Subchondral bone	pt_PT
dc.subject	Hyaline cartilage	pt_PT
dc.title	Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.title	Journal of Functional Biomaterials	pt_PT
oaire.citation.volume	Vol. 12, n.º 1	pt_PT
person.familyName	Morouço
person.familyName	Fernandes
person.givenName	Pedro
person.givenName	Cristiana Henriques
person.identifier	435983
person.identifier.ciencia-id	F619-3996-742A
person.identifier.ciencia-id	0C18-D3D1-D625
person.identifier.orcid	0000-0002-5956-9790
person.identifier.orcid	0000-0001-6371-800X
person.identifier.rid	K-9545-2013
person.identifier.scopus-author-id	24339135400
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isAuthorOfPublication	05b28d80-9e18-41cc-a66c-f37955bfc8da
relation.isAuthorOfPublication	b2b4ceb5-27a6-4c69-8726-48abb8261063
relation.isAuthorOfPublication.latestForDiscovery	05b28d80-9e18-41cc-a66c-f37955bfc8da