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Adjunctive role of Calyptranthes tricona extract with probiotic Kluyveromyces marxianus on colorectal adenocarcinoma Caco-2 cells

2019Journal article Restricted access
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dc.contributor.authorKich, Débora Mara
dc.contributor.authorBitencourt, Shanna
dc.contributor.authorFaleiro, Dalana
dc.contributor.authorImmich, Sheila Mariele
dc.contributor.authorMarmitt, Diorge Jonatas
dc.contributor.authorBaldasso, Tamara
dc.contributor.authorHaute, Gabriela Viegas
dc.contributor.authorOliveira, Jarbas Rodrigues de
dc.contributor.authorLaufer, Stefan
dc.contributor.authorPedrosa, Rui
dc.contributor.authorSouza, Claucia Fernanda Volken de
dc.contributor.authorGoettert, Márcia Inês
dc.date.accessioned2020-07-17T13:59:38Z
dc.date.available2020-07-17T13:59:38Z
dc.date.issued2019
dc.descriptionThis work was supported by University of Vale do Taquari (Univates)CNPq, Conselho Nacional de Desenvolvimento Cientifico e Tecnológico(CNpq)45645/2014/8 and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 001.pt_PT
dc.description.abstractThe composition of microbiota may influence the development of colorectal cancer (CRC). In addition, probiotics can decrease the chance of developing cancer or its progress. For that reason, it is encouraging to assess the influence of plant extracts as adjuvants of the health-promoting effects of probiotics. Thus, this study aimed to investigate the in vitro beneficial properties of Calyptranthes tricona leaf ethanol extract in association or not with the lactic yeast Kluyveromyces marxianus on colon adenocarcinoma Caco-2 cells. C. tricona extract inhibited the in vitro p38α MAPK activity and exhibited immunomodulation on isolated human lymphocytes. Further, the extract did not induce cytotoxicity towards K. marxianus or Caco-2 cells; leading to an increased yeast adhesion to cells in a dose-dependent manner. In conclusion, this preliminary study demonstrates that C. tricona extract has effects on enzyme inhibition and immune function. In addition, when associated with K. marxianus, C. tricona may possess beneficial properties for application as enhancer of probiotic’s protective role on CRC cells. However, further studies are necessary in order to elucidate the mechanisms involved.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationKich, D.M., Bitencourt, S., Faleiro, D., Immich, S.M., Marmitt, D.J., Baldasso, T., Haute, G.V., Oliveira, J.R., Laufer, S., Pedrosa, R., Souza, C.F.V. & Goettert, M.I. (2019). Adjunctive role of Calyptranthes tricona extract with probiotic Kluyveromyces marxianus on colorectal adenocarcinoma Caco-2 cells. Phytochemistry Letters, 30, 1-5. 10.1016/j.phytol.2019.01.001.pt_PT
dc.identifier.doidoi.org/10.1016/j.phytol.2019.01.001pt_PT
dc.identifier.issn1874-3900
dc.identifier.urihttp://hdl.handle.net/10400.8/5024
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPlant extractpt_PT
dc.subjectMyrtaceaept_PT
dc.subjectYeastpt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectImmunitypt_PT
dc.titleAdjunctive role of Calyptranthes tricona extract with probiotic Kluyveromyces marxianus on colorectal adenocarcinoma Caco-2 cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePhytochemistry Letterspt_PT
oaire.citation.volume30pt_PT
person.familyNamePedrosa
person.givenNameRui
person.identifier349272
person.identifier.ciencia-id3817-33DE-919E
person.identifier.orcid0000-0003-0970-0575
person.identifier.ridB-4815-2015
person.identifier.scopus-author-id7005010300
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication94496a40-57cf-472f-94e1-5db9d5da78b6
relation.isAuthorOfPublication.latestForDiscovery94496a40-57cf-472f-94e1-5db9d5da78b6

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