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Increased short-term risk of cardiovascular events in inflammatory rheumatic diseases: Results from a population-based cohort

2021Journal article Restricted access
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dc.contributor.authorDa Silva Domingues, Vital
dc.contributor.authorRodrigues, Ana M.
dc.contributor.authorDias, Sara Simões
dc.contributor.authorDelgado, Luís
dc.contributor.authorBarkoudah, Ebrahim
dc.contributor.authorBranco, J
dc.contributor.authorCanhao, H
dc.date.accessioned2022-04-04T12:26:38Z
dc.date.available2022-04-04T12:26:38Z
dc.date.issued2021
dc.description.abstractCardiovascular diseases represent the frst cause of death globally. Infammatory rheumatic disease (IRMD) patients, due to their lifelong infammatory status, are at increased risk of developing premature cardiovascular disease. We aimed to assess the risk for cardiovascular events (CVE) in a population-based study. We followed 10,153 adults from the EpiDoC Cohort, a large Portuguese population-based prospective study (2011–2016). IRMD patients were identifed at baseline and followed during 5 years. CVE were defned as a composite of self-reported myocardial infarction or angina pectoris, arrhythmias, valvular disease, stroke or transient ischemic attack and peripheral artery disease. Statistical analysis was performed by utilizing multivariate logistic regression and goodness-of-ft and area under ROC curve. At baseline, IRMD patients had similar age as the non-IRMD participants (mean age 55 vs 53 years-old; 72.1% female); dyslipidaemia and sedentary lifestyle were more common (40.7% vs 31.4%, p=0.033; 87.3% vs 67%, p=0.016, respectively). During an average follow-up of 2.6 years, 26 CVE were reported among IRMD patients. IRMD patients had higher odd of CVE (OR 1.64, 95% CI 1.04–2.58; p=0.03), despite comparable mortality rates (1.7% vs 0.7%, p=0.806). A stepwise approach attained that gender, age, history of hypertension, body mass index, IRMD and follow-up time are the most important predictive variables of CVE (AUC 0.80). IRMD patients, at community level, have an increased short-term risk of major CVE when compared to non-IRMD, and that highlights the potential beneft of a systematic screening and more aggressive cardiovascular risk assessment and management of these patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDa Silva Domingues, V., Rodrigues, A.M., Dias, S.S. et al. Increased short-term risk of cardiovascular events in inflammatory rheumatic diseases: results from a population-based cohort. Rheumatol Int 41, 311–318 (2021). https://doi.org/10.1007/s00296-020-04754-7pt_PT
dc.identifier.doi10.1007/s00296-020-04754-7pt_PT
dc.identifier.eissn1437-160X
dc.identifier.urihttp://hdl.handle.net/10400.8/6900
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationgrant for clinical research from the Portuguese Society of Rheumatology and a grant from Portuguese Society of Rheumatology/ Pfzer 2017pt_PT
dc.relation.ispartofseries2;
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00296-020-04754-7pt_PT
dc.subjectRheumatic diseasespt_PT
dc.subjectInfammationpt_PT
dc.subjectCardiovascular diseasespt_PT
dc.subjectProspective studypt_PT
dc.subjectRisk assessmentpt_PT
dc.titleIncreased short-term risk of cardiovascular events in inflammatory rheumatic diseases: Results from a population-based cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage318pt_PT
oaire.citation.startPage311pt_PT
oaire.citation.titleRheumatology Internationalpt_PT
oaire.citation.volume41pt_PT
person.familyNameDa Silva Domingues
person.familyNameDias
person.familyNameBarkoudah
person.familyNameBranco
person.familyNameCanhão
person.givenNameVital
person.givenNameSara
person.givenNameEbrahim
person.givenNameJaime
person.givenNameHelena
person.identifierC-9611-2018
person.identifier.ciencia-idAA1F-9375-B5E6
person.identifier.ciencia-idB612-E5C3-60DC
person.identifier.ciencia-id5A17-C6D9-DBC8
person.identifier.orcid0000-0001-7339-0220
person.identifier.orcid0000-0001-6782-7481
person.identifier.orcid0000-0001-8224-5121
person.identifier.orcid0000-0001-7024-4375
person.identifier.orcid0000-0003-1894-4870
person.identifier.ridI-9965-2018
person.identifier.scopus-author-id57191257381
person.identifier.scopus-author-id33367487300
person.identifier.scopus-author-id8417815400
person.identifier.scopus-author-id6602393492
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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