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Co-Occurrence of ACSSuT and Cephalosporin Resistance Phenotypes Is Mediated by <i>int1-</i> Associated Elements in Nontyphoidal <i>Salmonella enterica</i> from Human Infections in Spain

2013-10Artigo científico Acesso restrito
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg02:Erradicar a Fome
datacite.subject.sdg08:Trabalho Digno e Crescimento Económico
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorCampos, Maria Jorge
dc.contributor.authorPalomo, Gonzalo
dc.contributor.authorHormeño, Lorena
dc.contributor.authorUgarte, María
dc.contributor.authorPorrero, María Concepción
dc.contributor.authorHerrera-León, Silvia
dc.contributor.authorVadillo, Santiago
dc.contributor.authorPíriz, Segundo
dc.contributor.authorQuesada, Alberto
dc.date.accessioned2026-04-09T10:41:50Z
dc.date.available2026-04-09T10:41:50Z
dc.date.issued2013-10
dc.description.abstractA screening of antimicrobial resistance and its genetic determinants has been performed on 300 Salmonella enterica isolates collected during 2004-2008 from human infections in Spain. Salmonella Typhimurium and Salmonella Enteritidis were the major serotypes, which were found with similar frequencies covering 80% of the bacterial collection. Salmonella Typhimurium isolates frequently shared low susceptibility to antimicrobials of the penta-resistance phenotype (ACSSuT) and/or cephalosporin resistance. The ACSSuT profile was found closely linked to int1-associated gene cassettes, with major elements carrying DNA fragments of 1.0 Kb (aadA2 gene) plus 1.2 Kb (blaPSE-1 gene) or 2.0 Kb (aadA1 and blaOXA-1 genes). Among these, ACSSuT and cephalosporin resistances were associated in Salmonella Typhimurium isolates expressing the blaOXA gene. β-lactamase activities were also detected from isolates carrying blaTEM, blaCMY, or blaSHV, although only the two last genes expressed extended-spectrum β-lactamases. The clonal analysis of S. enterica strains suggests that both horizontal and vertical transfer mechanisms are involved in the wide dissemination of their antimicrobial resistance.eng
dc.description.sponsorshipG.P. wishes to thank the Valhondo Calaff foundation for a predoctoral fellowship. This work has been supported by the Ministry of Education and Science of Spain (project AGL2008-04147/GAN), the Department of Employ, Enterprise and Innovation of the regional government of Extremadura, Spain (project PRI08B001 and group CTS001) and the University of Extremadura (Group MIVET).
dc.identifier.citationCampos, M. J., Palomo, G., Hormeno, L., Ugarte, M., Porrero, M. C., Herrera-León, S., ... & Quesada, A. (2013). Co-occurrence of ACSSuT and cephalosporin resistance phenotypes is mediated by int1-associated elements in nontyphoidal Salmonella enterica from human infections in Spain. Microbial Drug Resistance, 19(5), 384-391.
dc.identifier.doi10.1089/mdr.2012.0261
dc.identifier.issn1076-6294
dc.identifier.issn1931-8448
dc.identifier.urihttp://hdl.handle.net/10400.8/16079
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSAGE Publications
dc.relation.hasversionhttps://journals.sagepub.com/doi/abs/10.1089/mdr.2012.0261
dc.relation.ispartofMicrobial Drug Resistance
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAnti-Bacterial Agents
dc.subjectBeta-Lactamases
dc.subjectCephalosporin Resistance
dc.subjectCephalosporins
dc.titleCo-Occurrence of ACSSuT and Cephalosporin Resistance Phenotypes Is Mediated by <i>int1-</i> Associated Elements in Nontyphoidal <i>Salmonella enterica</i> from Human Infections in Spaineng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage391
oaire.citation.issue5
oaire.citation.startPage384
oaire.citation.titleMicrobial Drug Resistance
oaire.citation.volume19
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCampos
person.givenNameMaria Jorge
person.identifier174191
person.identifier.ciencia-id2416-7867-2D40
person.identifier.orcid0000-0002-0883-0610
person.identifier.ridE-5591-2014
person.identifier.scopus-author-id55767069800
relation.isAuthorOfPublication6d1bf3db-fdba-4bea-b65d-94491f841659
relation.isAuthorOfPublication.latestForDiscovery6d1bf3db-fdba-4bea-b65d-94491f841659

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