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Projeto de investigação
Strengthening excellence for advanced osteosarcoma’s predictive models
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Magnesium oxide coatings on thermoplastic polyurethane as a key approach to prevent catheter-associated infections
Publication . Padrão, Tatiana; Monteiro, Fernando J.; Sousa, Susana R.; Dias, Juliana R.
Central venous catheters (CVCs) are essential healthcare tools, but their use is often complicated by bacterial colonization on the catheter surface, leading to serious infections and life-threatening bloodstream complications. Current strategies, often reliant on antibiotics or antiseptics, are increasingly ineffective due to the rise of antimicrobial resistance. This study aimed to develop a novel antibacterial coating for CVCs by incorporating magnesium oxide (MgO) nanoparticles onto a thermoplastic polyurethane (TPU) film surface containing barium sulfate (BaSO4). The antibacterial efficacy of these coatings was evaluated against Staphylococcus epidermidis, a major pathogen in catheter-associated infections. The results showed that MgO coatings significantly inhibited bacterial growth in a concentration-dependent manner, with 0.50 % and 1.0 % MgO concentrations achieving complete eradication of both planktonic and adherent bacteria. Importantly, the coatings exhibited excellent cytocompatibility with fibroblasts and showed no significant impact on hemolysis or blood clotting. The 0.50 % MgO coating was identified as the optimal formulation, offering the best balance of potent antibacterial activity, cytocompatibility and hemocompatibility. This approach preserves the valuable physical and chemical properties of the TPU material while providing effective antibacterial protection. The straightforward and cost-effective coating process holds significant promise for industrial scale production, paving the way for a new generation of safer and more effective CVCs.
Current Strategies to Produce 3D Electrospun-Based Wound Dressings for Skin Regeneration
Publication . Ferreira, Carolina A. M.; Lemos, Marco F. L.; Maurício, Ana Colette; Dias, Juliana R.
Tissue engineering-based wound dressings are a promising treatment approach that mimics the native skin microenvironment to promote effective healing and tissue regeneration. In fact, those advanced wound dressings can be made by electrospinning which has revolutionized the field of wound healing by developing biostructures that closely mimic the skin’s extracellular matrix (ECM). To date, most electrospinning research has focused on composition and materials rather than exploring advanced deposition strategies. Conventional electrospinning using random, aligned fibers, co-electrospinning, core-shell approaches, or redesigned collectors has achieved significant results in wound healing, which are discussed in this article. However, these approaches lack the development of realistic 3D structures. To achieve that, advancing approaches through the combination of electrospinning with different techniques such as gas foaming, short nanofiber assembly, or 3D printing significantly enhance skin regeneration of deep wounds (full-thickness and chronic wounds) compared to 2D structures. This review highlights the latest developments, design principles, and recent breakthroughs in electrospinning structures for skin regeneration and provides a fresh perspective for upcoming research in the field of 3D electrospun-based structures.
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European Commission
European Commission
European Commission
Programa de financiamento
HORIZON Action Grant Budget-Based
HORIZON Coordination and Support Actions
HORIZON Coordination and Support Actions
Número da atribuição
101079372