Percorrer por autor "Fernandes, Sofia"
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- Fructose Malabsorption, Gut Microbiota and Clinical Consequences: A Narrative Review of the Current EvidencePublication . Simões, Catarina D.; Sousa, Ana Sofia; Fernandes, Sofia; Sarmento, AméliaFructose malabsorption is characterized as the incomplete absorption of fructose in the small intestine. Fructose is one of the most common monosaccharides in the human diet. The purpose of this review is to provide an updated overview of insights into the relationship between high-fructose diet, fructose malabsorption, gut microbiota and clinical consequences. Incomplete absorption of fructose causes accumulation in the colon, which leads to fermentation by gut microbiota and abdominal symptoms such as bloating and excessive gas production. Malabsorption mayresult from exceeding theabsorptive capacity of GLUT5orinsufficient upregulation, with incidence increasing with age and higher dietary fructose concentrations. High-fructose diets generally promote an increase in inflammatory bacterial groups such as Desulfovibrio and Deferribacteraceae, while reducing beneficial Bacteroidetes. These microbial alterations may impair intestinal barrier function, modify short-chain fatty acid profiles, and contribute to systemic inflammation, metabolic disorAcademic Editors: Edyta Juszczuk-Kubiak and Katarzyna Góralska Received: 19 October 2025 Revised: 5 November 2025 Accepted: 5 November 2025 Published: 6 November 2025 Citation: Simões, C.D.; Sousa, A.S.; Fernandes, S.; Sarmento, A. Fructose Malabsorption, Gut Microbiota and Clinical Consequences: A Narrative Review of the Current Evidence. Life 2025, 15, 1720. https://doi.org/ 10.3390/life15111720 Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/). ders, and potentially mental health issues. Animal studies using fructose malabsorption models present inconclusive results regarding the impact of fructose on the composition of gut microbiota. Additional research is essential to fully comprehend the complex relationship between diet, fructose malabsorption and gut microbiota, to develop personalized, effective dietary approaches for managing symptoms of fructose malabsorption.
- How to correctly estimate the electric field in capacitively coupled systems for tissue engineering: a comparative studyPublication . Meneses, João; Fernandes, Sofia; Alves, Nuno; Pascoal-Faria, Paula; Miranda, Pedro CavaleiroCapacitively Coupled (CCoupled) electric fields are used to stimulate cell cultures in Tissue Engineering. Knowing the electric field (E-Field) magnitude in the culture medium is fundamental to establish a relationship between stimulus strength and cellular effects. We analysed eight CCoupled studies and sought to corroborate the reported estimates of the E-Field in the culture medium. First, we reviewed the basic physics underlying CCoupled stimulation and delineated three approaches to estimate the E-field. Using these approaches, we found that the reported values were overestimated in five studies, four of which were based on incorrect assumptions. In all studies, insufficient information was provided to reproduce the setup exactly. Creating electrical models of the experimental setup should improve the accuracy of the E-field estimates and enhance reproducibility. For this purpose, we developed a free open-source tool, the E-field Calculator for CCoupled systems, which is available for download from an internet hosting platform.