Repository logo
 
Publication

Scaffolds and Bioreactor characterisation towards Bone Regeneration: proposal of a computer-aided design model

2019-10-24Master thesis Restricted access
Simple item page
datacite.subject.fosEngenharia e Tecnologia::Outras Engenharias e Tecnologiaspt_PT
dc.contributor.advisorVieira, Paula Cristina Rodrigues Pascoal Faria
dc.contributor.advisorAscenso, Rita Margarida Teixeira
dc.contributor.advisorMoura, Carla Sofia Monteiro de
dc.contributor.authorFernandes, Cristiana Henriques
dc.date.accessioned2020-01-16T17:33:56Z
dc.date.available2020-01-16T17:33:56Z
dc.date.issued2019-10-24
dc.description.abstractOver the last decades, the number of occupational accidents associated with bone problems has increased leading to a growing concern worldwide. Currently, autografts, allografts, and xenografts are used for bone regeneration. However, their application have associated risks. Tissue Engineering (TE) has investigated solutions to address these problems, specifically through the production of temporary supports, also called biocompatible and biodegradable scaffolds, which allow cell adhesion and proliferation, providing mechanical support to the formation of new bone tissue. These three-dimensional supports must meet certain requirements, namely mechanical and biological. Upon its production and in order to give an appropriate answer, the material must be biocompatible as well as the products derived from its degradation. The combination of materials and structure with the technique to be used will directly influence their physical and chemical properties and, consequently, their action in contributing to bone regeneration. Thus, the focus of this dissertation is to perform a critical analysis of the state-of-art in bone TE and present a proposal of an optimized temporary support geometry. For this, the choice of biomaterials, cells and their culture conditions (static vs. dynamic) and/or the addition of growth factors for the repair of large bone defects are addressed is addressed.pt_PT
dc.identifier.tid202368416pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.8/4440
dc.language.isoengpt_PT
dc.relationProjects insitu.Biomas (POCI-01-0247-FEDER-017771) and Stimuli2Bioscaffolds (PTDC/EME-SIS/32554/2017)pt_PT
dc.subjectBioreactorpt_PT
dc.subjectBone regeneration CADpt_PT
dc.subjectScaffoldspt_PT
dc.subjectTissue engineeringpt_PT
dc.titleScaffolds and Bioreactor characterisation towards Bone Regeneration: proposal of a computer-aided design modelpt_PT
dc.typemaster thesis
dspace.entity.typePublication
person.familyNameFernandes
person.givenNameCristiana Henriques
person.identifier.ciencia-id0C18-D3D1-D625
person.identifier.orcid0000-0001-6371-800X
rcaap.rightsrestrictedAccesspt_PT
rcaap.typemasterThesispt_PT
relation.isAuthorOfPublicationb2b4ceb5-27a6-4c69-8726-48abb8261063
relation.isAuthorOfPublication.latestForDiscoveryb2b4ceb5-27a6-4c69-8726-48abb8261063
thesis.degree.nameMestrado em Gestão de Sistemas de Informação Médicapt_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
(V. Corrigida) Cristiana Fernandes - Dissertação.pdf
Size:
2.29 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.32 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTG - Mestrado em Gestão de Sistemas de Informação Médica