Combination of 3D Extruded-based Poly (ɛ-caprolactone) Scaffolds with Mesenchymal Stem/Stromal Cells: Strategy Optimization

Moura, Carla Sofia; Silva, Cláudia Lobato da; Bartolo, Paulo Jorge; Ferreira, Frederico Castelo

Publication

Combination of 3D Extruded-based Poly (ɛ-caprolactone) Scaffolds with Mesenchymal Stem/Stromal Cells: Strategy Optimization

2015Journal article

datacite.subject.fos	Engenharia e Tecnologia
datacite.subject.sdg	09:Indústria, Inovação e Infraestruturas
dc.contributor.author	Moura, Carla Sofia
dc.contributor.author	Silva, Cláudia Lobato da
dc.contributor.author	Bartolo, Paulo Jorge
dc.contributor.author	Ferreira, Frederico Castelo
dc.date.accessioned	2025-12-15T11:03:15Z
dc.date.available	2025-12-15T11:03:15Z
dc.date.issued	2015
dc.description	Conference name 4th International Conference on Tissue Engineering - An ECCOMAS Thematic Conference, ICTE 2015, Lisbon
dc.description	Conference date 25 June 2015 - 27 June 2015
dc.description	Part of special issue 4th International Conference on Tissue Engineering, ICTE2015, An ECCOMAS Thematic Conference
dc.description.abstract	This study uses a combination of 3D extruded-based biodegradable scaffolds and human bone marrow-derived mesenchymal stem/stromal cells to understand how scaffold properties can contribute for efficient cell seeding, proliferation and migration. Highly interconnected porous poly(ɛ-caprolactone) scaffolds were produced by a layer-by-layer extrusion. Two configurations were studied with larger (390 μm) or smaller pore size (190 μm) at the centre. MSC, seeded on the top centre of the scaffold surface, increased 5 folds after 13 days of cultivation for both configurations, allowing us to conclude that in this range of pore sizes pose no limitations for cell migration are observed.	eng
dc.description.sponsorship	This research is sponsored by the Portuguese Foundation for Science and Technology through SFRH/BD/73970/2010, IF/00442/2012 and MIT Portugal Program, Bioengineering Systems Focus Area.
dc.description.sponsorship	Sponsors: European Community Association on Computational Methods in Applied Sciences, ECCOMAS idmec IPL TAP Portgual Tecnico Lisboa
dc.identifier.citation	Monteiro de Moura, Carla Sofia & Silva, Cláudia & Bártolo, Paulo & Ferreira, Frederico. (2015). Combination of 3D Extruded-based Poly (ɛ-caprolactone) Scaffolds with Mesenchymal Stem/Stromal Cells: Strategy Optimization. Procedia Engineering. 110. 122-127. 10.1016/j.proeng.2015.07.019.
dc.identifier.doi	10.1016/j.proeng.2015.07.019
dc.identifier.issn	1877-7058
dc.identifier.uri	http://hdl.handle.net/10400.8/15035
dc.language.iso	eng
dc.peerreviewed	yes
dc.publisher	Elsevier
dc.relation	DESIGN AND FABRICATION OF ZONAL CARTILAGE CONSTRUCTS
dc.relation.hasversion	https://www.sciencedirect.com/science/article/pii/S1877705815012606
dc.relation.ispartof	Procedia Engineering
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject	Mesenchymal stem/stromal cells
dc.subject	Poly (ε-caprolactone)
dc.subject	Scaffolds
dc.subject	Tissue engineering
dc.title	Combination of 3D Extruded-based Poly (ɛ-caprolactone) Scaffolds with Mesenchymal Stem/Stromal Cells: Strategy Optimization	eng
dc.title.alternative	4th International Conference on Tissue Engineering, ICTE2015	eng
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	DESIGN AND FABRICATION OF ZONAL CARTILAGE CONSTRUCTS
oaire.awardURI	info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F73970%2F2010/PT
oaire.citation.endPage	127
oaire.citation.startPage	122
oaire.citation.title	Procedia Engineering
oaire.citation.volume	110
oaire.version	http://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyName	Monteiro de Moura
person.familyName	Bartolo
person.givenName	Carla Sofia
person.givenName	Paulo
person.identifier	203086
person.identifier.ciencia-id	671C-8FEC-A14A
person.identifier.ciencia-id	5810-9BF9-4522
person.identifier.orcid	0000-0003-2610-1005
person.identifier.orcid	0000-0003-3683-726X
person.identifier.rid	F-2421-2013
person.identifier.scopus-author-id	6603353041
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
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