Combination of 3D Extruded-based Poly (ɛ-caprolactone) Scaffolds with Mesenchymal Stem/Stromal Cells: Strategy Optimization

Moura, Carla Sofia; Silva, Cláudia Lobato da; Bartolo, Paulo Jorge; Ferreira, Frederico Castelo

http://hdl.handle.net/10400.8/15035

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Authors

Moura, Carla Sofia

Silva, Cláudia Lobato da

Bartolo, Paulo Jorge

Ferreira, Frederico Castelo

Abstract(s)

This study uses a combination of 3D extruded-based biodegradable scaffolds and human bone marrow-derived mesenchymal stem/stromal cells to understand how scaffold properties can contribute for efficient cell seeding, proliferation and migration. Highly interconnected porous poly(ɛ-caprolactone) scaffolds were produced by a layer-by-layer extrusion. Two configurations were studied with larger (390 μm) or smaller pore size (190 μm) at the centre. MSC, seeded on the top centre of the scaffold surface, increased 5 folds after 13 days of cultivation for both configurations, allowing us to conclude that in this range of pore sizes pose no limitations for cell migration are observed.

Description

Conference name 4th International Conference on Tissue Engineering - An ECCOMAS Thematic Conference, ICTE 2015, Lisbon
Conference date 25 June 2015 - 27 June 2015
Part of special issue 4th International Conference on Tissue Engineering, ICTE2015, An ECCOMAS Thematic Conference

Keywords

Mesenchymal stem/stromal cells Poly (ε-caprolactone) Scaffolds Tissue engineering

URI

http://hdl.handle.net/10400.8/15035

Citation

Monteiro de Moura, Carla Sofia & Silva, Cláudia & Bártolo, Paulo & Ferreira, Frederico. (2015). Combination of 3D Extruded-based Poly (ɛ-caprolactone) Scaffolds with Mesenchymal Stem/Stromal Cells: Strategy Optimization. Procedia Engineering. 110. 122-127. 10.1016/j.proeng.2015.07.019.