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Do GnRH Agonists Really Increase Body Weight Gain? Evaluation of a Multicentric Portuguese Cohort of Patients With Central Precocious Puberty

2022-03-04Journal article Open access
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dc.contributor.authorLeite, Ana Luísa
dc.contributor.authorGalo, Elisa
dc.contributor.authorAntunes, Ana
dc.contributor.authorRobalo, Brígida
dc.contributor.authorAmaral, Daniela
dc.contributor.authorEspada, Filipa
dc.contributor.authorCastro, Sofia
dc.contributor.authorDias, Sara Simões
dc.contributor.authorLimbert, Catarina
dc.date.accessioned2023-06-07T14:10:56Z
dc.date.available2023-06-07T14:10:56Z
dc.date.issued2022-03-04
dc.description.abstractIntroduction: There are several concerns associated with gonadotropin-releasing hormone agonist (GnRHa) treatment for central precocious puberty (CPP), such as obesity and changes in body mass index (BMI). We aimed to investigate whether any anthropometric differences exist and if they persist over time. Methods: We conducted an observational study of Portuguese children (both sexes) diagnosed with CPP between January 2000 and December 2017, using a digital platform, in order to analyze the influence of GnRHa treatment on BMI-SD score (BMI-SDS). Results: Of the 241 patients diagnosed with CPP, we assessed 92 patients (8% boys) in this study. At baseline, 39% of the patients were overweight. BMI-SDS increased with treatment for girls but then diminished 1 year after stopping GnRHa therapy (p = 0.018). BMI-SDS variation at the end of treatment was negatively correlated with BMI-SDS at baseline (p < 0.001). Boys grew taller and faster during treatment than did girls (p < 0.001), and therefore, their BMI-SDS trajectory might be different. Conclusions: This study showed an increase of body weight gain during GnRHa treatment only in girls, which reversed just 1 year after stopping treatment. The overall gain in BMI-SDS with treatment is associated with baseline BMI-SDS.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLeite AL, Galo E, Antunes A, Robalo B, Amaral D, Espada F, Castro S, Simões Dias S and Limbert C (2022) Do GnRH Agonists Really Increase Body Weight Gain? Evaluation of a Multicentric Portuguese Cohort of Patients With Central Precocious Puberty. Front. Pediatr. 10:816635. doi: 10.3389/fped.2022.816635pt_PT
dc.identifier.doihttps://doi.org/10.3389/fped.2022.816635pt_PT
dc.identifier.eissn2296-2360
dc.identifier.other816635
dc.identifier.urihttp://hdl.handle.net/10400.8/8569
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fped.2022.816635/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCentral precocious puberty (CPP)pt_PT
dc.subjectGnRH agonistspt_PT
dc.subjectWeight gain (WG)pt_PT
dc.subjectBody mass index (BMI)pt_PT
dc.subjectObesitypt_PT
dc.titleDo GnRH Agonists Really Increase Body Weight Gain? Evaluation of a Multicentric Portuguese Cohort of Patients With Central Precocious Pubertypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Pediatricspt_PT
oaire.citation.volume10pt_PT
person.familyNameDias
person.givenNameSara
person.identifier.ciencia-idAA1F-9375-B5E6
person.identifier.orcid0000-0001-6782-7481
person.identifier.ridI-9965-2018
person.identifier.scopus-author-id33367487300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa49e0bc6-cfea-4033-aebf-a1ef9e4c5e7b
relation.isAuthorOfPublication.latestForDiscoverya49e0bc6-cfea-4033-aebf-a1ef9e4c5e7b

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