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Characterisation of PCL and PCL/PLA Scaffolds for Tissue Engineering

2013Comunicação em conferência Acesso aberto
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datacite.subject.fosCiências Médicas::Biotecnologia Médica
datacite.subject.fosEngenharia e Tecnologia::Engenharia dos Materiais
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorPatrício, T.
dc.contributor.authorDomingos, M.
dc.contributor.authorA. Gloria
dc.contributor.authorBártolo, P.
dc.date.accessioned2026-03-24T10:33:11Z
dc.date.available2026-03-24T10:33:11Z
dc.date.issued2013
dc.description.abstractThis paper investigates the use of PCL and PCL/PLA scaffolds produced using a novel additive biomanufacturing system called BioCell Printing. PCL/PLA blends were prepared using melt blend and solvent casting techniques. Scaffolds with 0/90° architecture and 350 μm of pore size were morphologically evaluated using scanning electron microscopy and atomic force microscopy. Biological tests, using osteosarcoma cell line G-63, were performed using the Alamar Blue Assay and Alkaline Phosphatase Activity. Results show that the BioCell Printing system produces scaffolds with regular and reproducible architecture, presenting no toxicity and enhancing cell attachment and proliferation. It was also possible to observe that the addition of PLA to PCL scaffolds strongly improves the biomechanical performance of the constructs.eng
dc.description.sponsorshipThe Strategic Project (PEST-OE/EME/UI4044/2011) funded by the Portuguese Foundation for Science and Technology supported this work. The authors of this work also acknowledge the JPK Instruments.
dc.identifier.citationT. Patrício, M. Domingos, A. Gloria, P. Bártolo, Characterisation of PCL and PCL/PLA Scaffolds for Tissue Engineering, Procedia CIRP, Volume 5, 2013, Pages 110-114, ISSN 2212-8271, https://doi.org/10.1016/j.procir.2013.01.022.
dc.identifier.doi10.1016/j.procir.2013.01.022
dc.identifier.issn2212-8271
dc.identifier.urihttp://hdl.handle.net/10400.8/15954
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationStrategic Project - UI 4044 - 2011-2012
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S2212827113000231?via%3Dihub
dc.relation.ispartofProcedia CIRP
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBiomanufacturing
dc.subjectPolymer blends
dc.subjectScaffolds
dc.subjectTissue Engineering
dc.titleCharacterisation of PCL and PCL/PLA Scaffolds for Tissue Engineeringeng
dc.typeconference paper
dspace.entity.typePublication
oaire.awardNumberPEst-OE/EME/UI4044/2011
oaire.awardTitleStrategic Project - UI 4044 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEME%2FUI4044%2F2011/PT
oaire.citation.conferenceDate2013
oaire.citation.endPage114
oaire.citation.startPage110
oaire.citation.titleProcedia CIRP
oaire.citation.volume5
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFernandes Patrício
person.familyNameDomingos
person.familyNameBartolo
person.givenNameTatiana Marisa
person.givenNameMarco
person.givenNamePaulo
person.identifierL-2781-2015
person.identifier203086
person.identifier.ciencia-idEF1C-430E-9F29
person.identifier.ciencia-idB512-2D06-5897
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0003-0672-9014
person.identifier.orcid0000-0002-6693-790X
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id55749853300
person.identifier.scopus-author-id6603353041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationc256ec7c-9a07-42d9-84a2-6885b5392a00
relation.isAuthorOfPublication1fb3bd4b-f499-4db6-93c1-3a671f116d07
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relation.isProjectOfPublication44bd1c93-9ee1-4685-a408-c2baa61ffbcd
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