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Cytoprotective effect of seaweeds with high antioxidant activity from the Peniche coast (Portugal)

2017Journal article Restricted access
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dc.contributor.authorPinteus, Susete
dc.contributor.authorSilva, Joana
dc.contributor.authorAlves, Celso
dc.contributor.authorHorta, André
dc.contributor.authorFino, Nádia
dc.contributor.authorRodrigues, Ana Inês
dc.contributor.authorMendes, Susana
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2021-08-24T15:11:01Z
dc.date.available2021-08-24T15:11:01Z
dc.date.issued2017
dc.description.abstractScreening of antioxidant potential of dichloromethane and methanolic extracts of twenty-seven seaweeds from the Peniche coast was performed by: total phenolic contents (TPC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and oxygen radical absorbance capacity (ORAC). Seaweeds revealing the highest antioxidant activity were screened for cytoprotective potential in MCF-7 cells, including the mitochondrial membrane potential analysis and the caspase-9 activity. High correlation was found between TPC of seaweed extracts and their scavenging capacity on DPPH and peroxyl radicals. The highest antioxidant activity was displayed by the methanolic fraction of brown seaweeds belonging to Fucales, however Ulva compressa presented the highest cytoprotective effect by blunting the apoptosis process. These results suggest that high antioxidant activity may not be directly related with high cytoprotective potential. Thus, seaweeds reveal to be a promising source of compounds with potential against oxidative stress.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSusete Pinteus, Joana Silva, Celso Alves, André Horta, Nádia Fino, Ana Inês Rodrigues, Susana Mendes, Rui Pedrosa, Cytoprotective effect of seaweeds with high antioxidant activity from the Peniche coast (Portugal), Food Chemistry, Volume 218, 2017, Pages 591-599, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2016.09.067.pt_PT
dc.identifier.doihttp://dx.doi.org/10.1016/j.foodchem.2016.09.067pt_PT
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10400.8/6146
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0308814616314509pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMarine natural productspt_PT
dc.subjectTotal phenolic contentpt_PT
dc.subjectRadical scavenging activitypt_PT
dc.subjectOxidative stresspt_PT
dc.subjectAlgae extractspt_PT
dc.subjectTumor cell linept_PT
dc.titleCytoprotective effect of seaweeds with high antioxidant activity from the Peniche coast (Portugal)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage599pt_PT
oaire.citation.startPage591pt_PT
oaire.citation.titleFood Chemistrypt_PT
oaire.citation.volume218pt_PT
person.familyNamePinteus
person.familyNameSilva
person.familyNameAlves
person.familyNameHorta
person.familyNameMENDES
person.familyNamePedrosa
person.givenNameSusete
person.givenNameJoana
person.givenNameCelso
person.givenNameAndré
person.givenNameSUSANA
person.givenNameRui
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person.identifier.orcid0000-0003-0970-0575
person.identifier.ridB-3366-2017
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rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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