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In vitro activities of Ceiba speciosa (A.St.-Hil) Ravenna aqueous stem bark extract

2018Journal article Restricted access
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dc.contributor.authorDörr, Juliana Andréa
dc.contributor.authorBitencourt, Shanna
dc.contributor.authorBortoluzzi, Luísa
dc.contributor.authorAlves, Celso
dc.contributor.authorSilva, Joana
dc.contributor.authorBoligon, Aline Augusti
dc.contributor.authorSantos, Roberto Christ Vianna
dc.contributor.authorLaufer, Stefan
dc.contributor.authorPedrosa, Rui
dc.contributor.authorGoettert, Márcia Inês
dc.date.accessioned2021-08-23T15:06:47Z
dc.date.available2021-08-23T15:06:47Z
dc.date.issued2018
dc.description.abstractSeveral species of the genus Ceiba (Malvaceae) are ethnopharmacologically used. Thus, this study aimed to investigate the in vitro beneficial properties of the aqueous stem bark extract of Ceiba speciosa. The extract presented a great amount of phenolic compounds (117.4 ± 6.2 mg GAE/g). The antioxidant activity was assessed by DPPH (IC50 = 42.87 μg/mL), ORAC (2351.17 μmol TE/g) and FRAP (235.94 μM FeSO4/g) methods. In addition, the extract reduced MCF-7 cell viability as assessed by MTT. However, it prevented mitochondrial membrane depolarization and reduced caspase-9 activity induced by hydrogen peroxide. In conclusion, these findings indicate the extract is an excellent source of natural antioxidants and is able to protect ROS-induced cell death. Therefore, C. speciosa extract may possess beneficial properties for application in pharmaceutical industry as an antioxidant. However, further studies to better elucidate its mechanisms and to isolate its active compounds are required.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJuliana Andréa Dörr, Shanna Bitencourt, Luísa Bortoluzzi, Celso Alves, Joana Silva, Stefani Stoll, Susete Pinteus, Aline Augusti Boligon, Roberto Christ Vianna Santos, Stefan Laufer, Rui Pedrosa & Márcia Inês Goettert (2019) In vitro activities of Ceiba speciosa (A.St.-Hil) Ravenna aqueous stem bark extract, Natural Product Research, 33:23, 3441-3444, DOI: 10.1080/14786419.2018.1478823pt_PT
dc.identifier.doi10.1080/14786419.2018.1478823pt_PT
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.urihttp://hdl.handle.net/10400.8/6144
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCeiba speciosapt_PT
dc.subjectMalvaceaept_PT
dc.subjectPolyphenolspt_PT
dc.subjectAntioxidantpt_PT
dc.subjectMitochondrialpt_PT
dc.subjectDepolarizationpt_PT
dc.subjectCaspase-9pt_PT
dc.titleIn vitro activities of Ceiba speciosa (A.St.-Hil) Ravenna aqueous stem bark extractpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3444pt_PT
oaire.citation.issue23pt_PT
oaire.citation.startPage3441pt_PT
oaire.citation.titleNatural Product Researchpt_PT
oaire.citation.volume33pt_PT
person.familyNameAlves
person.familyNameSilva
person.familyNamePedrosa
person.givenNameCelso
person.givenNameJoana
person.givenNameRui
person.identifier159091
person.identifier98885
person.identifier349272
person.identifier.ciencia-id501C-F268-2E60
person.identifier.ciencia-id6317-6F15-BA35
person.identifier.ciencia-id3817-33DE-919E
person.identifier.orcid0000-0003-1581-2127
person.identifier.orcid0000-0003-1224-1699
person.identifier.orcid0000-0003-0970-0575
person.identifier.ridB-3366-2017
person.identifier.ridB-4815-2015
person.identifier.scopus-author-id55654969100
person.identifier.scopus-author-id56370819800
person.identifier.scopus-author-id7005010300
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery23e68f76-0f7a-4f39-9da8-f1a26e2e2cd7

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