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Changes in Metabolic and Inflammatory Markers after a Combined Exercise Program in Workers: A Randomized Controlled Trial

2024-10-14Journal article Restricted access
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dc.contributor.authorSilva, Fernanda
dc.contributor.authorDuarte-Mendes, Pedro
dc.contributor.authorFerreira, José Pedro
dc.contributor.authorCarvalho, Eugenia
dc.contributor.authorMonteiro, Diogo
dc.contributor.authorA, Massart
dc.contributor.authorFarinha, Carlos
dc.contributor.authorSOARES, CM.
dc.contributor.authorA, Teixeira
dc.date.accessioned2024-10-18T09:47:21Z
dc.date.embargo2025-10-15
dc.date.issued2024-10-14
dc.description.abstractPurpose We investigated the effects of a 16-week combined exercise training on body composition, and metabolic and inflammatory markers in sedentary middle-aged workers. We also assessed whether alterations in metabolic markers were associated with changes in health-related outcomes. Methods This randomized controlled trial involved 46 participants randomly allocated into control and exercise groups. The exercise group performed 16-wk combined aerobic and resistance training for 75 min per session, 3 times a week. Fasting blood samples were collected at baseline and after 16-wk intervention to determine lipid profile, and metabolic and inflammatory markers as primary outcomes. Results A total of 36 participants completed the intervention (53.70 ± 6.92 yr old; n = 18 in each group). Waist circumference (interaction effect: F = 7.423, P = 0.002), fat mass (interaction effect: F = 5.070, P = 0.011), and muscle mass (interaction effect: F = 5.420, P = 0.007) were improved in the exercise group compared with the control group. Fasting glucose increased after the 16-wk follow-up (time effect: F = 73.253, P < 0.001), without an intergroup difference. Insulin levels were greater in the control compared with exercise group (group effect: F = 6.509, P = 0.015). The control group tended to increase the homeostatic model assessment of insulin resistance index (interaction effect: F = 3.493, P = 0.070) and to decrease the QUICKI index (interaction effect: F = 3.364, P = 0.075) to a greater extent compared with the exercise group. Exercise group reduced leptin (interaction effect: F = 11.175, P = 0.002) and adiponectin (interaction effect: F = 4.437, P = 0.043) concentrations in a greater magnitude than the control group. Interleukin (IL)-6 (time effect: F = 17.767, P < 0.001) and tumor necrosis factor α (time effect: F = 9.781, P = 0.004) concentrations decreased after the intervention, without an intergroup difference. IL-17A levels increased in the control compared with exercise group (interaction effect: F = 5.010, P = 0.033). Effects on adiponectin, IL-6, and IL-17A levels seem to depend on baseline body mass index, age, and sex. Percentage changes in leptin correlated positively with changes in homeostatic model assessment of insulin resistance index in the exercise (r = 0.565, P = 0.015) and control (r = 0.670, P = 0.002) groups. Conclusions A combined training program can be an effective strategy to improve body composition and inflammatory markers and prevent marked reductions in insulin sensitivity among middle-aged workers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSILVA, FERNANDA M.1; DUARTE-MENDES, PEDRO2,3,4; FERREIRA, JOSÉ P.1; CARVALHO, EUGÉNIA5,6; MONTEIRO, DIOGO7,8; MASSART, ALAIN1; FARINHA, CARLOS3,4; SOARES, CARLOS M.1,9; TEIXEIRA, ANA M.1. Changes in Metabolic and Inflammatory Markers after a Combined Exercise Program in Workers: A Randomized Controlled Trial. Medicine & Science in Sports & Exercise 56(11):p 2156-2172, November 2024. | DOI: 10.1249/MSS.0000000000003510pt_PT
dc.identifier.doi10.1249/MSS.0000000000003510pt_PT
dc.identifier.issn0195-9131
dc.identifier.urihttp://hdl.handle.net/10400.8/10175
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLippincottpt_PT
dc.relation.publisherversionhttps://journals.lww.com/acsm-msse/abstract/2024/11000/changes_in_metabolic_and_inflammatory_markers.7.aspxpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectMiddle-agept_PT
dc.subjectInflammationpt_PT
dc.subjectInsulinpt_PT
dc.subjectResistancept_PT
dc.subjectPhysical activitypt_PT
dc.subjectSedentary bheaviorpt_PT
dc.subjectT2D Preventionpt_PT
dc.titleChanges in Metabolic and Inflammatory Markers after a Combined Exercise Program in Workers: A Randomized Controlled Trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEstados Unidos da Américapt_PT
oaire.citation.endPage2172pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage2156pt_PT
oaire.citation.titleMedicine & Science in Sports & Exercisept_PT
oaire.citation.volume56pt_PT
person.familyNameAntunes da Silva
person.familyNameDuarte-Mendes
person.familyNameLeitão Ferreira
person.familyNameLOURENÇO DE CARVALHO
person.familyNameMonteiro
person.familyNameMassart
person.familyNameNunes Farinha
person.familyNameTeixeira
person.givenNameFernanda Maria
person.givenNamePedro
person.givenNameJosé Pedro
person.givenNameEUGÉNIA MARIA
person.givenNameDiogo
person.givenNameAlain Guy Marie
person.givenNameCarlos Manuel
person.givenNameAna
person.identifierrid7830
person.identifierhttps://scholar.google.com/citations?user=AHvtGSEAAAAJ&hl=en
person.identifierF-1202-2015
person.identifier285388
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person.identifier.ciencia-id0A1E-945F-F010
person.identifier.ciencia-idCD19-424E-F14F
person.identifier.ciencia-id4B15-EC24-6644
person.identifier.orcid0000-0001-8019-0729
person.identifier.orcid0000-0001-5055-2696
person.identifier.orcid0000-0002-4427-3276
person.identifier.orcid0000-0001-6264-3632
person.identifier.orcid0000-0002-7179-6814
person.identifier.orcid0000-0003-3977-7266
person.identifier.orcid0000-0001-5794-4916
person.identifier.orcid0000-0003-1498-949X
person.identifier.ridO-3427-2018
person.identifier.scopus-author-idhttps://www.scopus.com/authid/detail.uri?authorId=35083236900
person.identifier.scopus-author-id56437945500
person.identifier.scopus-author-id35729198900
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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