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Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight results

2018Journal article Restricted access
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dc.contributor.authorÂngelo, David Faustino
dc.contributor.authorMorouço, Pedro
dc.contributor.authorGil, Florêncio Monje
dc.contributor.authorMónico, Lisete
dc.contributor.authorGonzález-Garcia, Raúl
dc.contributor.authorSousa, Rita
dc.contributor.authorNeto, Lia
dc.contributor.authorCaldeira, Inês
dc.contributor.authorSmith, Margaret
dc.contributor.authorSmith, Susan
dc.contributor.authorSanz, David
dc.contributor.authorSantos, Fábio Abade dos
dc.contributor.authorPinho, Mário
dc.contributor.authorCarrapiço, Belmira
dc.contributor.authorCavaco, Sandra
dc.contributor.authorMoura, Carla
dc.contributor.authorAlves, Nuno
dc.contributor.authorSalvado, Francisco
dc.contributor.authorLittle, Christopher
dc.date.accessioned2023-04-24T13:13:42Z
dc.date.available2023-04-24T13:13:42Z
dc.date.issued2018
dc.descriptionThis study was granted by Portuguese Grunenthal Foundation, Secção Regional Oeste da Ordem dos Médicos, Sociedade Anatómica Portuguesa e Associação Anatómica Portuguesa.pt_PT
dc.description.abstractIntroduction: The role of temporomandibular joint (TMJ) surgery is not well defined due to a lack of quality randomized controlled clinical trials, comparing different TMJ surgical treatments with medical and placebo interventions. The temporomandibular joint interposal study (TEMPOJIMS) is a rigorous preclinical trial divided in 2 phases. In phase 1 the authors investigated the role of the TMJ disc and in phase 2 the authors evaluated 3 different interposal materials. The present work of TEMPOJIMS e phase 1, aims to evaluate histopathologic and imaging changes of bilateral discectomy and discopexy in Black Merino sheep TMJ, using a high-quality trial following the ARRIVE guidelines. Material and methods: This randomized, blinded and controlled preclinical trial was conducted in 9 Black Merino sheep to investigate histopathologic (primary outcome), imaging and body weight (secondary outcomes) changes after bilateral discectomy, discopexy and sham surgery. Results: Significant changes were noticed in discectomy group, both in imaging and histopathologic analyses. Body weight changes were most pronounced in the discectomy group in the first 4 months after surgery with recovery to baseline weight 6 months after surgery. Discopexy induced nonsignificant changes in histopathologic, imaging and body weight analyses. Conclusions: This study reinforces the importance of developing an effective interposal material to substitute the TMJ disc and the need to explore the molecular mechanisms that underlie TMJ cartilage degeneration. The study design proposed in TEMPOJIMS represents an important progress towards future rigorous TMJ investigations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDavid Faustino Ângelo, Pedro Morouço, Florencio Monje Gil, Lisete Mónico, Raúl González-Gárcia, Rita Sousa, Lia Neto, Inês Caldeira, Margaret Smith, Susan Smith, David Sanz, Fábio Abade dos Santos, Mário Pinho, Belmira Carrapiço, Sandra Cavaco, Carla Moura, Nuno Alves, Francisco Salvado, Christopher Little, Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS – Phase 1- histologic, imaging and body weight results, Journal of Cranio-Maxillofacial Surgery, Volume 46, Issue 4, 2018, Pages 688-696, ISSN 1010-5182, https://doi.org/10.1016/j.jcms.2018.01.006pt_PT
dc.identifier.doi10.1016/j.jcms.2018.01.006pt_PT
dc.identifier.issn1010-5182
dc.identifier.urihttp://hdl.handle.net/10400.8/8446
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1010518218300192pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPreclinical studypt_PT
dc.subjectTMJ discectomypt_PT
dc.subjectTMJ discopexypt_PT
dc.subjectTMJ imagingpt_PT
dc.subjectTMJ histologypt_PT
dc.subjectTMJ discpt_PT
dc.titlePreclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight resultspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage696pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage688pt_PT
oaire.citation.titleJournal of Cranio-Maxillo-Facial Surgerypt_PT
oaire.citation.volume46pt_PT
person.familyNameÂngelo
person.familyNameMorouço
person.familyNameMonteiro de Moura
person.familyNameAlves
person.givenNameDavid
person.givenNamePedro
person.givenNameCarla Sofia
person.givenNameNuno
person.identifier435983
person.identifier452149
person.identifier.ciencia-id2C1B-F1D5-5A08
person.identifier.ciencia-idF619-3996-742A
person.identifier.ciencia-id671C-8FEC-A14A
person.identifier.ciencia-id311E-1559-8F6C
person.identifier.orcid0000-0001-8411-9946
person.identifier.orcid0000-0002-5956-9790
person.identifier.orcid0000-0003-2610-1005
person.identifier.orcid0000-0002-5016-0868
person.identifier.ridK-9545-2013
person.identifier.ridN-4073-2013
person.identifier.scopus-author-id24339135400
person.identifier.scopus-author-id7006403383
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6d9ebcd1-9dd6-48a8-916d-3ca7b9c912eb
relation.isAuthorOfPublication05b28d80-9e18-41cc-a66c-f37955bfc8da
relation.isAuthorOfPublication33d084bb-ac8d-454a-ac58-25be1331ce04
relation.isAuthorOfPublicationbbd46a74-b77e-4539-a5fe-62ee95cdc4fa
relation.isAuthorOfPublication.latestForDiscovery33d084bb-ac8d-454a-ac58-25be1331ce04

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