Effects of bilateral discectomy and bilateral discopexy on black Merino sheep rumination kinematics: TEMPOJIMS – phase 1 – pilot blinded, randomized preclinical study

Background The temporomandibular joint interposal study (TEMPOJIMS) is a rigorous preclinical trial divided in 2 phases. In phase 1 the authors investigated the role of the TMJ disc and in phase 2 the authors evaluated 3 different interposal materials. The present work of TEMPOJIMS - phase 1, investigated the effects of bilateral discectomy and discopexy in sheep mastication and rumination. Methods This randomized, blinded and controlled preclinical trial (in line with the ARRIVE guidelines) was conducted in 9 Black Merino sheep to evaluate changes in mastication and rumination after bilateral discectomy and bilateral discopexy, by comparing with a sham surgery control group. The outcomes evaluated were: (1) absolute masticatory time; (2) ruminant time per cycle; (3) ruminant kinematics, and (4) ruminant area. After baseline evaluation and surgical interventions, the outcomes were recorded over 3 successive days, every 30 days, for 6 months. Results The first month after intervention seemed to be the critical period for significant kinematic changes in the discectomy and discopexy groups. However, 6 months after the bilateral interventions, no significant changes were noticed when compared with the control group. Conclusions In this study, bilateral discectomy and discopexy had no significant effect in mastication and ruminatory movement. The introduction of kinematic evaluation presents a new challenge that may contribute to the improvement of future studies on the TMJ domain.

Keywords

TMJ Preclinical trial Discopexy Discectomy Kinematics Black merino sheep

URI

http://hdl.handle.net/10400.8/13516

Citation

David Faustino Ângelo, Florencio Monje Gil, Raúl González-García, Lisete Mónico, Rita Sousa, Lia Neto, Inês Caldeira, Carla Moura, Luís Carlos Francisco, David Sanz, Nuno Alves, Francisco Salvado, Pedro Morouço, Effects of bilateral discectomy and bilateral discopexy on black Merino sheep rumination kinematics: TEMPOJIMS – phase 1 – pilot blinded, randomized preclinical study, Journal of Cranio-Maxillofacial Surgery, Volume 46, Issue 2, 2018, Pages 346-355, ISSN 1010-5182, https://doi.org/10.1016/j.jcms.2017.11.022.