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Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius

2015Journal article Open access
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dc.contributor.authorRodrigues, Daniel
dc.contributor.authorAlves, Celso
dc.contributor.authorHorta, André
dc.contributor.authorPinteus, Susete
dc.contributor.authorSilva, Joana
dc.contributor.authorCulioli, Gérald
dc.contributor.authorThomas, Olivier P.
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2021-08-12T12:22:37Z
dc.date.available2021-08-12T12:22:37Z
dc.date.issued2015
dc.descriptionAcknowledgments : This work was supported through funding provided by the European Commission Collaborative Project FP7 number 265896-www.bammbo.eu). One of the authors (G.C.) was partially supported by CNRS (Côte d’Azur delegation-DR 20). J.-M. Guigonis from the Plate-Forme Bernard Rossi of Nice is acknowledged for recording HRMS spectra.
dc.description.abstractCancer and infectious diseases continue to be a major public health problem, and new drugs are necessary. As marine organisms are well known to provide a wide range of original compounds, the aim of this study was to investigate the bioactivity of the main constituents of the cosmopolitan red alga, Sphaerococcus coronopifolius. The structure of several bromoditerpenes was determined by extensive spectroscopic analysis and comparison with literature data. Five molecules were isolated and characterized which include a new brominated diterpene belonging to the rare dactylomelane family and named sphaerodactylomelol (1), along with four already known sphaerane bromoditerpenes (2–5). Antitumor activity was assessed by cytotoxicity and anti-proliferative assays on an in vitro model of human hepatocellular carcinoma (HepG-2 cells). Antimicrobial activity was evaluated against four pathogenic microorganisms: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. Compound 4 exhibited the highest antimicrobial activity against S. aureus (IC50 6.35 μM) and compound 5 the highest anti-proliferative activity on HepG-2 cells (IC50 42.9 μM). The new diterpene, sphaerodactylomelol (1), induced inhibition of cell proliferation (IC50 280 μM) and cytotoxicity (IC50 720 μM) on HepG-2 cells and showed antimicrobial activity against S. aureus (IC50 96.3 μM).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRodrigues, D.; Alves, C.; Horta, A.; Pinteus, S.; Silva, J.; Culioli, G.; Thomas, O.P.; Pedrosa, R. Antitumor and Antimicrobial Potential of Bromoditerpenes Isolated from the Red Alga, Sphaerococcus coronopifolius. Mar. Drugs 2015, 13, 713-726. https://doi.org/10.3390/md13020713pt_PT
dc.identifier.doi10.3390/md13020713pt_PT
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.8/6084
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationSustainable production of biologically active molecules of marine based origin
dc.subjectRed algaept_PT
dc.subjectSphaerococcuspt_PT
dc.subjectDiterpenespt_PT
dc.subjectSphaeranept_PT
dc.subjectDactylomelanept_PT
dc.subjectHepG-2pt_PT
dc.subjectPathogenic microorganismspt_PT
dc.titleAntitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifoliuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSustainable production of biologically active molecules of marine based origin
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/265896/EU
oaire.citation.endPage726pt_PT
oaire.citation.startPage713pt_PT
oaire.citation.titleMarine drugspt_PT
oaire.citation.volume13pt_PT
oaire.fundingStreamFP7
person.familyNameRodrigues
person.familyNameAlves
person.familyNameHorta
person.familyNamePinteus
person.familyNameSilva
person.familyNamePedrosa
person.givenNameDaniel
person.givenNameCelso
person.givenNameAndré
person.givenNameSusete
person.givenNameJoana
person.givenNameRui
person.identifier159091
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person.identifier.orcid0000-0002-0162-8065
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person.identifier.orcid0000-0002-3290-3111
person.identifier.orcid0000-0003-1224-1699
person.identifier.orcid0000-0003-0970-0575
person.identifier.ridB-2980-2015
person.identifier.ridB-3366-2017
person.identifier.ridB-4815-2015
person.identifier.scopus-author-id55654969100
person.identifier.scopus-author-id55655320600
person.identifier.scopus-author-id55655328300
person.identifier.scopus-author-id56370819800
person.identifier.scopus-author-id7005010300
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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