Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins

Type 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin and ABA signaling in vivo. We show that ABA binds to PYR1, which in turn binds to and inhibits PP2Cs. We conclude that PYR/PYLs are ABA receptors functioning at the apex of a negative regulatory pathway that controls ABA signaling by inhibiting PP2Cs. Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy.

Description

O texto integral não está disponível no Repositório. Está disponível em acesso restrito em: http://www.sciencemag.org/cgi/content/abstract/324/5930/1068

Keywords

Abscisic acid Type 2C protein phosphatases

URI

http://hdl.handle.net/10400.8/136

Citation

PARK, Sang-Youl e outros - Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. Vol. 324, n.º 5930 (2009), pp. 1068-1071.