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Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins

2009-05Journal article Restricted access
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dc.contributor.authorPark, Sang-Youl
dc.contributor.authorFung, Pauline
dc.contributor.authorNishimura, Noriyuki
dc.contributor.authorJensen, Davin R.
dc.contributor.authorFujii, Hiroaki
dc.contributor.authorZhao, Yang
dc.contributor.authorLumba, Shelley
dc.contributor.authorSantiago, Julia
dc.contributor.authorRodrigues, Américo
dc.contributor.authorChow, Tsz-fung F.
dc.contributor.authorAlfred, Simon E.
dc.contributor.authorBonetta, Dario
dc.contributor.authorFinkelstein, Ruth
dc.contributor.authorProvart, Nicholas J.
dc.contributor.authorDesveaux, Darrell
dc.contributor.authorRodriguez, Pedro L.
dc.contributor.authorMcCourt, Peter
dc.contributor.authorZhu, Jian-Kang
dc.contributor.authorSchroeder, Julian I.
dc.contributor.authorVolkman, Brian F.
dc.contributor.authorCutler, Sean R.
dc.date.accessioned2009-08-20T10:01:13Z
dc.date.available2009-08-20T10:01:13Z
dc.date.issued2009-05
dc.descriptionO texto integral não está disponível no Repositório. Está disponível em acesso restrito em: http://www.sciencemag.org/cgi/content/abstract/324/5930/1068pt
dc.description.abstractType 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin and ABA signaling in vivo. We show that ABA binds to PYR1, which in turn binds to and inhibits PP2Cs. We conclude that PYR/PYLs are ABA receptors functioning at the apex of a negative regulatory pathway that controls ABA signaling by inhibiting PP2Cs. Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy.pt
dc.identifier.citationPARK, Sang-Youl e outros - Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. Vol. 324, n.º 5930 (2009), pp. 1068-1071.pt
dc.identifier.urihttp://hdl.handle.net/10400.8/136
dc.language.isoengpt
dc.subjectAbscisic acidpt
dc.subjectType 2C protein phosphatasespt
dc.titleAbscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteinspt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1071pt
oaire.citation.startPage1068pt
oaire.citation.titleSciencept
person.familyNameRodrigues
person.givenNameAmérico
person.identifier.orcid0000-0002-5293-5583
person.identifier.ridF-9573-2010
person.identifier.scopus-author-id15745701600
rcaap.rightsrestrictedAccess
rcaap.typearticlept
relation.isAuthorOfPublication718ad6e8-1d3a-4ce3-9870-e4ed6732c30b
relation.isAuthorOfPublication.latestForDiscovery718ad6e8-1d3a-4ce3-9870-e4ed6732c30b

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