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Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency

2025-09Journal article Open access
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datacite.subject.fosEngenharia e Tecnologia
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg10:Reduzir as Desigualdades
dc.contributor.authorLagoa, Ricardo
dc.contributor.authorRajan, Logesh
dc.contributor.authorViolante, Cristiana
dc.contributor.authorBabiaka, Smith B.
dc.contributor.authorMarques da Silva, Dorinda
dc.contributor.authorKapoor, Bhupinder
dc.contributor.authorReis, Flávio
dc.contributor.authorAtanasov, Atanas G.
dc.date.accessioned2025-07-23T17:18:55Z
dc.date.available2025-07-23T17:18:55Z
dc.date.issued2025-09
dc.descriptionArticle number - 108568
dc.description.abstractCurcumin, a natural compound found in turmeric, has shown promise in treating brain-related diseases and conditions associated with aging. Curcumin has shown multiple anti-inflammatory and brain-protective effects, but its clinical use is limited by challenges like poor absorption, specificity and delivery to the right tissues. A range of contemporary approaches at the intersection with bioengineering and systems biology are being explored to address these challenges. Data from preclinical and human studies highlight various neuroprotective actions of curcumin, including the inhibition of neuroinflammation, modulation of critical cellular signaling pathways, promotion of neurogenesis, and regulation of dopamine levels. However, curcumin’s multifaceted effects - such as its impact on microRNAs and senescence markers - suggest novel therapeutic targets in neurodegeneration. Tetrahydrocurcumin, a primary metabolite of curcumin, also shows potential due to its presence in circulation and its anti-inflammatory properties, although further research is needed to elucidate its neuroprotective mechanisms. Recent advancements in delivery systems, particularly brain-targeting nanocarriers like polymersomes, micelles, and liposomes, have shown promise in enhancing curcumin’s bioavailability and therapeutic efficacy in animal models. Furthermore, the exploration of drug-laden scaffolds and dermal delivery may extend the pharmacological applications of curcumin. Studies reviewed here indicate that engineered dermal formulations and devices could serve as viable alternatives for neuroprotective treatments and to manage skin or musculoskeletal inflammation. This work highlights the need for carefully designed, long-term studies to better understand how curcumin and its bioactive metabolites work, their safety, and their effectiveness.eng
dc.description.sponsorshipR.L. and D.M.S. acknowledge funding from their research units supported by national funds through Fundação para a Ciência e Tecnologia (FCT—Portugal)/MCTES (PIDDAC): LSRE-LCM, UIDB/50020/2020 and UIDP/50020/2020; ALiCE, LA/P/0045/2020; UCIBIO, UIDB/04378/2020 and UIDP/04378/2020; i4HB, LA/P/0140/2020. F.R. knowledges support from FCT/MCTES (CIBB strategic project UIDP/ 04539/2020) and European Union‘s Horizon Europe program (lence Hubs – HORIZON-WIDERA-2022-ACCESS-04-01), under the grant agreement #101087071.
dc.identifier.citationRicardo Lagoa, Logesh Rajan, Cristiana Violante, Smith B. Babiaka, Dorinda Marques-da-Silva, Bhupinder Kapoor, Flávio Reis, Atanas G. Atanasov, Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency, Biotechnology Advances, Volume 82, 2025, 108568, ISSN 0734-9750, https://doi.org/10.1016/j.biotechadv.2025.108568
dc.identifier.doi10.1016/j.biotechadv.2025.108568
dc.identifier.issn0734-9750
dc.identifier.urihttp://hdl.handle.net/10400.8/13765
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationInstitute for Health and Bioeconomy
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0734975025000540
dc.relation.ispartofBiotechnology Advances
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPolyphenols
dc.subjectAntioxidants
dc.subjectNetwork pharmacology
dc.subjectAlzheimer’s disease
dc.subjectParkinson’s disease
dc.subjectTurmeric
dc.subjectHeterologous production
dc.subjectNanoparticles
dc.subjectTissue engineering
dc.titleApplication of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiencyeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/13764
oaire.citation.titleBiotechnology Advances
oaire.citation.volume82
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_e19f295774971610
person.familyNameLagoa
person.familyNameViolante
person.familyNameMarques da Silva
person.givenNameRicardo
person.givenNameCristiana
person.givenNameDorinda
person.identifier124357
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0003-2375-6612
person.identifier.orcid0009-0003-6081-0427
person.identifier.orcid0000-0003-0460-5421
person.identifier.scopus-author-id23051352300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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