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Evaluation of antimicrobials residues in farmed gilthead seabream (Sparus aurata) after administration through medicated feed

2018-04Journal article Open access
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dc.contributor.authorRosa, João
dc.contributor.authorLeston, Sara
dc.contributor.authorCastro, Maria
dc.contributor.authorFreitas, Andreia
dc.contributor.authorBarbosa, Jorge
dc.contributor.authorPardal, Miguel Ângelo
dc.contributor.authorRema, Paulo
dc.contributor.authorDias, Jorge
dc.contributor.authorRamos, Fernando
dc.date.accessioned2025-06-27T10:59:29Z
dc.date.available2025-06-27T10:59:29Z
dc.date.issued2018-04
dc.description.abstractThe use of antimicrobials in aquaculture is a well-known fact and merits the focus of the scientific community. In the present study, five drugs (oxytetracycline, sulfadiazine, trimethoprim, oxolinic acid and flumequine) were selected to assess their retention in muscle tissues from gilthead seabream (Sparus aurata). Fish were placed in 150 L tanks at 18 °C, and fed for 7 days with experimental diets containing two concentrations of each antimicrobial (ranging from 5.51 to 131.16 mg kg−1). Edible tissues were then analyzed through a validated multi-class quantification method (UHPLC-MS/MS). The results indicate that sulfadiazine concentrations were the highest immediately after the feeding period and decreased towards day 3. Flumequine was only detected on the first day with concentrations below the MRL. Both trimethoprim and oxolinic acid concentrations were below the MRLs 3 days after the feeding period was over (oxolinic acid was not detected in muscle samples at day 14 for prophylaxis and day 28 for both treatments). Oxytetracycline residues in muscle tissues were the highest through time, with concentrations above the MRL for 7 days (Cday7 of 111.2 and 157.2 μg kg−1 for both dosages). Results suggest that these antimicrobials can be present in gilthead seabream muscle samples for longer periods than previously reported, when realistic conditions are tested. With the exception of oxytetracycline, concentrations were below the MRLs established 3 days after the feeding trial was over meaning that adverse effects related to human consumption are not likely. Nevertheless, allergic reactions or resistance to antimicrobials can be developed if low concentrations of such compounds are ingested on a frequent basis, as is the case of the Mediterranean diet.eng
dc.description.sponsorshipFinancial support was given by FEDER through the Operational Program for Competitiveness Factors e COMPETE, through FCT e the Portuguese Foundation for Science and Technology e under project PTDC/AGR/ALI/122119/2010; as well as the grant attributed to Sara Leston (grant SFRH/BPD/91828/2012) and to Joao Rosa (grant SFRH/BD/102008/2014). The funding source did not interfere with the study design, or in the collection, analysis or interpretation of the data. It also had no involvement in the writing of the report and in the decision to submit the present manuscript for publication.
dc.identifier.citationJoão Rosa, Sara Leston, Maria Castro, Andreia Freitas, Jorge Barbosa, Miguel Ângelo Pardal, Paulo Rema, Jorge Dias, Fernando Ramos, Evaluation of antimicrobials residues in farmed gilthead seabream (Sparus aurata) after administration through medicated feed, Food Control, Volume 86, 2018, Pages 110-116, ISSN 0956-7135, https://doi.org/10.1016/j.foodcont.2017.11.005.
dc.identifier.doi10.1016/j.foodcont.2017.11.005
dc.identifier.issn0956-7135
dc.identifier.urihttp://hdl.handle.net/10400.8/13436
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier BV
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0956713517305273
dc.relation.ispartofFood Control
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectWithdrawal times
dc.subjectGilthead seabream
dc.subjectAntimicrobials
dc.subjectMedicated feed
dc.subjectRetention
dc.titleEvaluation of antimicrobials residues in farmed gilthead seabream (Sparus aurata) after administration through medicated feedeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage116
oaire.citation.startPage110
oaire.citation.titleFood control
oaire.citation.volume86
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLeston
person.givenNameSara
person.identifier2837046
person.identifier.ciencia-idFF1E-B886-EB6C
person.identifier.orcid0000-0002-9040-2294
person.identifier.ridV-2570-2017
person.identifier.scopus-author-id15728205400
relation.isAuthorOfPublication1492bade-6429-4704-983b-5fa79c376013
relation.isAuthorOfPublication.latestForDiscovery1492bade-6429-4704-983b-5fa79c376013

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