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Growth Performance after Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish

datacite.subject.fosCiências Agrárias::Agricultura, Silvicultura e Pescas
datacite.subject.fosCiências Agrárias::Ciência Animal e dos Laticínios
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg14:Proteger a Vida Marinha
dc.contributor.authorGodino-Gimeno, Alejandra
dc.contributor.authorSánchez, Elisa
dc.contributor.authorGuillot, Raúl
dc.contributor.authorRocha, Ana
dc.contributor.authorAngotzi, Anna Rita
dc.contributor.authorLeal, Esther
dc.contributor.authorRotllant, Josep
dc.contributor.authorCerdá-Reverter, José Miguel
dc.date.accessioned2025-07-18T15:27:17Z
dc.date.available2025-07-18T15:27:17Z
dc.date.issued2020-12-09
dc.description.abstractThe melanocortin system is a key structure in the regulation of energy balance. Overexpression of inverse agonists, agouti-signaling protein (ASIP), and agouti-related protein (AGRP) results in increased food intake, linear growth, and body weight. ASIP regulates dorsal-ventral pigment polarity through melanocortin 1 receptor (MC1R) and overexpression induces obesity in mice by binding to central MC4R. Asip1 overexpression in transgenic zebrafish (asip1-Tg) enhances growth, yet experiments show fish overexpressing Asip1 do not develop obesity even under severe feeding regimes. Asip1-Tg fish do not need to eat more to grow larger and faster; thus, increased food efficiency can be observed. In addition, asip1-Tg fish reared at high density are able to grow far more than wild-type (WT) fish reared at low density, although asip1-Tg fish seem to be more sensitive to crowding stress than WT fish, thus making the melanocortin system a target for sustainable aquaculture, especially as the U.S. Food and Drug Association has recently approved transgenic fish trading.eng
dc.identifier.citationGodino-Gimeno A, Sánchez E, Guillot R, Rocha A, Angotzi AR, Leal E, Rotllant J, Cerdá-Reverter JM. Growth Performance After Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish. Zebrafish. 2020 Dec;17(6):373-381. doi: https://doi.org/10.1089/zeb.2020.1932. Epub 2020 Oct 28. PMID: 33112719.
dc.identifier.doi10.1089/zeb.2020.1932
dc.identifier.eissn1557-8542
dc.identifier.issn1545-8547
dc.identifier.urihttp://hdl.handle.net/10400.8/13721
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMary Ann Liebert
dc.relation.hasversionhttps://www.liebertpub.com/doi/10.1089/zeb.2020.1932
dc.relation.ispartofZebrafish
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectgrowth
dc.subjectmelanocortin
dc.subjectobesity
dc.subjectstress
dc.subjecttransgenic
dc.subjectzebrafish
dc.titleGrowth Performance after Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafisheng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6
oaire.citation.titleZebrafish
oaire.citation.volume17
oaire.versionhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43
person.familyNameRocha
person.givenNameAna
person.identifier.orcid0000-0003-2165-5519
relation.isAuthorOfPublication1e3903a6-5662-4d1d-88bd-6790b3a3ae27
relation.isAuthorOfPublication.latestForDiscovery1e3903a6-5662-4d1d-88bd-6790b3a3ae27

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The melanocortin system is a key structure in the regulation of energy balance. Overexpression of inverse agonists, agouti-signaling protein (ASIP), and agouti-related protein (AGRP) results in increased food intake, linear growth, and body weight. ASIP regulates dorsal-ventral pigment polarity through melanocortin 1 receptor (MC1R) and overexpression induces obesity in mice by binding to central MC4R. Asip1 overexpression in transgenic zebrafish (asip1-Tg) enhances growth, yet experiments show fish overexpressing Asip1 do not develop obesity even under severe feeding regimes. Asip1-Tg fish do not need to eat more to grow larger and faster; thus, increased food efficiency can be observed. In addition, asip1-Tg fish reared at high density are able to grow far more than wild-type (WT) fish reared at low density, although asip1-Tg fish seem to be more sensitive to crowding stress than WT fish, thus making the melanocortin system a target for sustainable aquaculture, especially as the U.S. Food and Drug Association has recently approved transgenic fish trading.
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