Publication
Growth Performance after Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish
datacite.subject.fos | Ciências Agrárias::Agricultura, Silvicultura e Pescas | |
datacite.subject.fos | Ciências Agrárias::Ciência Animal e dos Laticínios | |
datacite.subject.fos | Ciências Naturais::Ciências Biológicas | |
datacite.subject.sdg | 12:Produção e Consumo Sustentáveis | |
datacite.subject.sdg | 13:Ação Climática | |
datacite.subject.sdg | 14:Proteger a Vida Marinha | |
dc.contributor.author | Godino-Gimeno, Alejandra | |
dc.contributor.author | Sánchez, Elisa | |
dc.contributor.author | Guillot, Raúl | |
dc.contributor.author | Rocha, Ana | |
dc.contributor.author | Angotzi, Anna Rita | |
dc.contributor.author | Leal, Esther | |
dc.contributor.author | Rotllant, Josep | |
dc.contributor.author | Cerdá-Reverter, José Miguel | |
dc.date.accessioned | 2025-07-18T15:27:17Z | |
dc.date.available | 2025-07-18T15:27:17Z | |
dc.date.issued | 2020-12-09 | |
dc.description.abstract | The melanocortin system is a key structure in the regulation of energy balance. Overexpression of inverse agonists, agouti-signaling protein (ASIP), and agouti-related protein (AGRP) results in increased food intake, linear growth, and body weight. ASIP regulates dorsal-ventral pigment polarity through melanocortin 1 receptor (MC1R) and overexpression induces obesity in mice by binding to central MC4R. Asip1 overexpression in transgenic zebrafish (asip1-Tg) enhances growth, yet experiments show fish overexpressing Asip1 do not develop obesity even under severe feeding regimes. Asip1-Tg fish do not need to eat more to grow larger and faster; thus, increased food efficiency can be observed. In addition, asip1-Tg fish reared at high density are able to grow far more than wild-type (WT) fish reared at low density, although asip1-Tg fish seem to be more sensitive to crowding stress than WT fish, thus making the melanocortin system a target for sustainable aquaculture, especially as the U.S. Food and Drug Association has recently approved transgenic fish trading. | eng |
dc.identifier.citation | Godino-Gimeno A, Sánchez E, Guillot R, Rocha A, Angotzi AR, Leal E, Rotllant J, Cerdá-Reverter JM. Growth Performance After Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish. Zebrafish. 2020 Dec;17(6):373-381. doi: https://doi.org/10.1089/zeb.2020.1932. Epub 2020 Oct 28. PMID: 33112719. | |
dc.identifier.doi | 10.1089/zeb.2020.1932 | |
dc.identifier.eissn | 1557-8542 | |
dc.identifier.issn | 1545-8547 | |
dc.identifier.uri | http://hdl.handle.net/10400.8/13721 | |
dc.language.iso | eng | |
dc.peerreviewed | yes | |
dc.publisher | Mary Ann Liebert | |
dc.relation.hasversion | https://www.liebertpub.com/doi/10.1089/zeb.2020.1932 | |
dc.relation.ispartof | Zebrafish | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | growth | |
dc.subject | melanocortin | |
dc.subject | obesity | |
dc.subject | stress | |
dc.subject | transgenic | |
dc.subject | zebrafish | |
dc.title | Growth Performance after Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish | eng |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.issue | 6 | |
oaire.citation.title | Zebrafish | |
oaire.citation.volume | 17 | |
oaire.version | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |
person.familyName | Rocha | |
person.givenName | Ana | |
person.identifier.orcid | 0000-0003-2165-5519 | |
relation.isAuthorOfPublication | 1e3903a6-5662-4d1d-88bd-6790b3a3ae27 | |
relation.isAuthorOfPublication.latestForDiscovery | 1e3903a6-5662-4d1d-88bd-6790b3a3ae27 |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Growth Performance after Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish_ab.pdf
- Size:
- 53.72 KB
- Format:
- Adobe Portable Document Format
- Description:
- The melanocortin system is a key structure in the regulation of energy balance. Overexpression of inverse agonists, agouti-signaling protein (ASIP), and agouti-related protein (AGRP) results in increased food intake, linear growth, and body weight. ASIP regulates dorsal-ventral pigment polarity through melanocortin 1 receptor (MC1R) and overexpression induces obesity in mice by binding to central MC4R. Asip1 overexpression in transgenic zebrafish (asip1-Tg) enhances growth, yet experiments show fish overexpressing Asip1 do not develop obesity even under severe feeding regimes. Asip1-Tg fish do not need to eat more to grow larger and faster; thus, increased food efficiency can be observed. In addition, asip1-Tg fish reared at high density are able to grow far more than wild-type (WT) fish reared at low density, although asip1-Tg fish seem to be more sensitive to crowding stress than WT fish, thus making the melanocortin system a target for sustainable aquaculture, especially as the U.S. Food and Drug Association has recently approved transgenic fish trading.
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.32 KB
- Format:
- Item-specific license agreed upon to submission
- Description: