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A Biorefinery Approach to the Biomass of the Seaweed Undaria pinnatifida (Harvey Suringar, 1873): Obtaining Phlorotannins-Enriched Extracts for Wound Healing

2021-03-19Journal article Open access
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dc.contributor.authorFerreira, Carolina A. M.
dc.contributor.authorFélix, Rafael
dc.contributor.authorFélix, Carina
dc.contributor.authorJanuário, Adriana P.
dc.contributor.authorAlves, Nuno
dc.contributor.authorNovais, Sara C.
dc.contributor.authorDias, Juliana R.
dc.contributor.authorLemos, Marco F.L.
dc.date.accessioned2023-03-15T14:53:31Z
dc.date.available2023-03-15T14:53:31Z
dc.date.issued2021-03-19
dc.description.abstractBrown seaweeds are recognized sources of compounds with a wide range of properties and applications. Within these compounds, phlorotannins are known to possess several bioactivities (e.g., antioxidant, anti-inflammatory, and antimicrobial) with potential to improve wound healing. To obtain phlorotannins enriched extracts from Undaria pinnatifida, a biorefinery was set using low cost industry-friendly methodologies, such as sequential solid–liquid extraction and liquid–liquid extraction. The obtained extracts were screened for their antioxidant and antimicrobial activity against five common wound pathogens and for their anti-inflammatory potential. The ethanolic wash fraction (wE100) had the highest antioxidant activity (114.61 ± 10.04 mmol·mg−1 extract by Diphenyl-1-picrylhydrazyl (DPPH) and 6.56 ± 1.13 mM eq. Fe II·mg−1 extract by and Ferric Reducing Antioxidant Power (FRAP)), acting efficiently against Gram-negative (Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria, and showing a nitric oxide production inhibition over 47% when used at 0.01 µg·mL−1 . NMR and FTIR chemical characterization suggested that phlorotannins are present. Obtained fraction wE100 proved to be a promising candidate for further inclusion as wound healing agents, while the remaining fractions analyzed are potential sources for other biotechnological applications, giving emphasis to a biorefinery and circular economy framework to add value to this seaweed and the industry.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira, C.A.M.; Félix, R.; Félix, C.; Januário, A.P.; Alves, N.; Novais, S.C.; Dias, J.R.; Lemos, M.F.L. A Biorefinery Approach to the Biomass of the Seaweed Undaria pinnatifida (Harvey Suringar, 1873): Obtaining Phlorotannins-Enriched Extracts for Wound Healing. Biomolecules 2021, 11, 461. https:// doi.org/10.3390/biom11030461pt_PT
dc.identifier.doi10.3390/biom11030461pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.8/8227
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPhlorotanninspt_PT
dc.subjectCircular economypt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectAnti-inflammatorypt_PT
dc.titleA Biorefinery Approach to the Biomass of the Seaweed Undaria pinnatifida (Harvey Suringar, 1873): Obtaining Phlorotannins-Enriched Extracts for Wound Healingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volumeVol. 11, n.º 3pt_PT
person.familyNameMarzia Ferreira
person.familyNameFaria da Costa Félix
person.familyNameFaria Da Costa Félix
person.familyNameJanuário
person.familyNameAlves
person.familyNameNovais
person.familyNameDias
person.familyNameLemos
person.givenNameCarolina Alexandra
person.givenNameRafael Alexandre
person.givenNameCarina Rafaela
person.givenNameAdriana P.
person.givenNameNuno
person.givenNameSara
person.givenNameJuliana
person.givenNameMarco
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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