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Comfortably numb: Ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on Phaeodactylum tricornutum

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dc.contributor.authorFeijão, Eduardo
dc.contributor.authorCarvalho, Ricardo da Cruz de
dc.contributor.authorDuarte, Irina A.
dc.contributor.authorMatos, Ana Rita
dc.contributor.authorCabrita, Maria Teresa
dc.contributor.authorBarreiro, Aldo
dc.contributor.authorLemos, Marco F.L.
dc.contributor.authorNovais, Sara C.
dc.contributor.authorMarques, João Carlos
dc.contributor.authorCaçador, Isabel
dc.contributor.authorReis-Santos, P.
dc.contributor.authorSilva, Marisa
dc.contributor.authorFonseca, Vanessa
dc.contributor.authorDuarte, Bernardo
dc.date.accessioned2021-08-23T12:38:12Z
dc.date.available2021-08-23T12:38:12Z
dc.date.issued2020
dc.descriptionThe authors would like to thank Fundaçao para a Ciencia e a Tecnologia (FCT) for funding the research via project grants PTDC/CTAAMB/30056/2017 (OPTOX), PTDC/AAG-MAA/1302/2014 (PROTEOME), UID/MAR/04292/2019 and UID/MULTI/04046/2013. B. Duarte and V. F. Fonseca were supported by investigation contracts (CEECIND/00511/2017 and DL57/2016/CP1479/CT0024). P. Reis-Santos was supported by FCT through a postdoctoral grant (SFRH/BPD/95784/ 2013). M.T.Cabrita is also supported by a DL57 investigation contract. Work was also funded by the Integrated Programme of SR&TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund.
dc.description.abstractEmerging pollutants such as pharmaceuticals are continuously released to aquatic environments posing a rising threat to marine ecosystems. Yet, monitoring routines and ecotoxicity data on biota worldwide for these substances are lacking. Non-steroidal anti-inflammatory drugs are among the most prescribed and found pharmaceuticals in aquatic environments. The toxicity effects of environmentally relevant concentrations of ibuprofen on primary productivity, oxidative stress and lipid metabolism of the diatom Phaeodactylum tricornutum were assessed. Diatom cultures were exposed to 0, 0.8, 3, 40, 100 and 300 μg L-1 ibuprofen concentrations, usually found in the vicinity of wastewater treatment plants and coastal environments. Higher concentrations (100 and 300 μg L-1) had a negative impact in P. triconutum growth, inhibiting the chloroplastic energy transduction in the electron transport chain resulting in lower energy reaching the PS I (r2 = - 0.55, p < 0.05). In contrast, the mitochondrial electron transport and available energy increased (r2 = 0.68 and r2 = 0.85, p < 0.05 respectively), mostly due to enhancements in lipid and protein contents as opposed to reduction of carbohydrates. A general up-regulation of the antioxidant enzymes could contributed to alleviate oxidative stress resulting in the decrease of lipid peroxidation products (r2 = 0.77, p < 0.05). Canonical analysis of principal components was performed and successfully discriminated exposure groups, with optical data excelling in classifying samples to different ibuprofen concentrations, being potentially used as environmental indicators. Finally, the identified mild to severe effects of ibuprofen on diatoms are likely to be exacerbated by the sustained use of this drug worldwide, underpinning the urgency of evaluating the impacts of this pharmaceutical on coastal and marine trophic webs.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarisa Silva, Eduardo Feijão, Ricardo da Cruz de Carvalho, Irina A. Duarte, Ana Rita Matos, Maria Teresa Cabrita, Aldo Barreiro, Marco F.L. Lemos, Sara C. Novais, João Carlos Marques, Isabel Caçador, Patrick Reis-Santos, Vanessa F. Fonseca, Bernardo Duarte, Comfortably numb: Ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on Phaeodactylum tricornutum, Marine Environmental Research, Volume 161, 2020, 105109, ISSN 0141-1136, https://doi.org/10.1016/j.marenvres.2020.105109.pt_PT
dc.identifier.doi10.1016/j.marenvres.2020.105109pt_PT
dc.identifier.issn0141-1136
dc.identifier.urihttp://hdl.handle.net/10400.8/6137
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationProTEoME - PROteomic Tools to assess Endocrine disruptiOn MEchanisms
dc.relationMARE - Marine and Environmental Sciences Centre
dc.relationBiosystems & Integrative Sciences Institute
dc.relationNot Available
dc.relationBIOCONNECT - CONECTIVIDADE EM POPULAÇÕES DE PEIXES ESTUARINOS E COSTEIROS: MARCADORES NATURAIS COMO UM INSTRUMENTO PARA GESTÃO E CONSERVAÇÃO
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141113620305225pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlgaept_PT
dc.subjectBiomarkerspt_PT
dc.subjectCanonical analysis of principal coordinatespt_PT
dc.subjectCoastal areaspt_PT
dc.subjectDiatompt_PT
dc.subjectEcotoxicologypt_PT
dc.subjectFatty acidspt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectPhotobiologypt_PT
dc.subjectPulse amplitude modulated (PAM) fluorometrypt_PT
dc.titleComfortably numb: Ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on Phaeodactylum tricornutumpt_PT
dc.typejournal article
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oaire.awardTitleBIOCONNECT - CONECTIVIDADE EM POPULAÇÕES DE PEIXES ESTUARINOS E COSTEIROS: MARCADORES NATURAIS COMO UM INSTRUMENTO PARA GESTÃO E CONSERVAÇÃO
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oaire.citation.titleMarine Environmental Researchpt_PT
oaire.citation.volume161pt_PT
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