Publication
Comparison of Three-dimensional Extruded Poly (ɛ-Caprolactone) and Polylactic acid Scaffolds with Pore size Variation
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| datacite.subject.sdg | 09:Indústria, Inovação e Infraestruturas | |
| datacite.subject.sdg | 12:Produção e Consumo Sustentáveis | |
| dc.contributor.author | Monteiro de Moura, Carla Sofia | |
| dc.contributor.author | Ferreira, Frederico Castelo | |
| dc.contributor.author | Bártolo, Paulo Jorge | |
| dc.date.accessioned | 2025-06-18T14:08:25Z | |
| dc.date.available | 2025-06-18T14:08:25Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | Additive manufacturing (AM) has become a prominent approach among the scientific community for the production of three-dimensional (3D) matrices able to support tissue engineering approaches, promoting cell adhesion, proliferation and organization aiming to repair different tissues, such as bone or cartilage. In this study we used an extrusion-based technique for the production of poly (ɛ-caprolactone) (PCL) and polylactic acid (PLA) scaffolds and performed a side-by-side scaffold characteristics comparison. Using this technique we were able to create fully 3D interconnected porous scaffolds with pore size variations ranging from 190 μm to 390 μm with both materials. These scaffolds were assessed for stiffness, wettability and cell adhesion using mesenchymal stem/stromal cells (MSC). Comparisons between these two materials were made. The compressive modulus obtained is on the same order of magnitude for both materials. However, PCL presents a statistically significant higher compressive modulus. Results confirmed that PCL is a more hydrophobic material, so it presents a lower wettability when compared to PLA. Interestingly cell adhesion is similar for PLA and PCL, therefore selection between these two materials for the use of this versatile platform can be defined according with biodegradability aimed. | eng |
| dc.description.sponsorship | This research is sponsored by the Portuguese Foundation for Science and Technology through SFRH/BD/73970/2010, IF/00442/2012 and MIT Portugal Program, Bioengineering Systems Focus Area. | |
| dc.identifier.citation | Carla Sofia Moura, Frederico Castelo Ferreira, Paulo Jorge Bártolo, Comparison of Three-dimensional Extruded Poly (ɛ-Caprolactone) and Polylactic acid Scaffolds with Pore size Variation, Procedia CIRP, Volume 49, 2016, Pages 209-212, ISSN 2212-8271, https://doi.org/10.1016/j.procir.2015.11.018 | |
| dc.identifier.doi | 10.1016/j.procir.2015.11.018 | |
| dc.identifier.issn | 2212-8271 | |
| dc.identifier.uri | http://hdl.handle.net/10400.8/13332 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Elsevier BV | |
| dc.relation | DESIGN AND FABRICATION OF ZONAL CARTILAGE CONSTRUCTS | |
| dc.relation | IF/00442/2012 | |
| dc.relation.hasversion | https://www.sciencedirect.com/science/article/pii/S2212827116302505 | |
| dc.relation.ispartof | Procedia CIRP | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Mesenchymal stem/stromal cells | |
| dc.subject | Poly (ɛ-caprolactone) | |
| dc.subject | Polylactic acid | |
| dc.subject | Scaffolds | |
| dc.title | Comparison of Three-dimensional Extruded Poly (ɛ-Caprolactone) and Polylactic acid Scaffolds with Pore size Variation | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | DESIGN AND FABRICATION OF ZONAL CARTILAGE CONSTRUCTS | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F73970%2F2010/PT | |
| oaire.citation.endPage | 212 | |
| oaire.citation.startPage | 209 | |
| oaire.citation.title | Procedia CIRP | |
| oaire.citation.volume | 49 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Monteiro de Moura | |
| person.givenName | Carla Sofia | |
| person.identifier.ciencia-id | 671C-8FEC-A14A | |
| person.identifier.orcid | 0000-0003-2610-1005 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| relation.isAuthorOfPublication | 33d084bb-ac8d-454a-ac58-25be1331ce04 | |
| relation.isAuthorOfPublication.latestForDiscovery | 33d084bb-ac8d-454a-ac58-25be1331ce04 | |
| relation.isProjectOfPublication | cdbe26aa-314b-4fc8-9f76-f3fda8820f2f | |
| relation.isProjectOfPublication.latestForDiscovery | cdbe26aa-314b-4fc8-9f76-f3fda8820f2f |