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In vitro activities of kappa-carrageenan isolated from red marine alga Hypnea musciformis: Antimicrobial, anticancer and neuroprotective potential

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dc.contributor.authorSouza, Ricardo Basto
dc.contributor.authorFrota, Annyta Fernandes
dc.contributor.authorSilva, Joana
dc.contributor.authorAlves, Celso
dc.contributor.authorNeugebauer, Agnieszka Zofia
dc.contributor.authorPinteus, Susete
dc.contributor.authorRodrigues, José Ariévilo Gurgel
dc.contributor.authorCordeiro, Edna Maria Silva
dc.contributor.authorAlmeida, Raimundo Rafael de
dc.contributor.authorPedrosa, Rui
dc.contributor.authorBenevides, Norma Maria Barros
dc.date.accessioned2020-07-06T14:27:41Z
dc.date.available2020-07-06T14:27:41Z
dc.date.issued2018
dc.description.abstractThis study assessed the antioxidant, antimicrobial, anticancer and neuroprotective activities of the kappa(k)-carrageenan isolated from the red alga Hypnea musciformis (Hm-SP). The chemical spectrum of the k-carrageenan fromHm-SPwas confirmed by Fourier transform infrared (FT-IR) spectroscopy.Hm-SP revealed an antibacterial and antifungal action against Staphylococcus aureus and Candida albicans, respectively. Hm-SP did not promoted cytotoxic effects against Human breast cancer (MCF-7) and Human neuroblastoma (SH-SY5Y) cell-lines. However, itwas observed a significant reduction of the cellular proliferation capacity in these cancer cells in presence of the Hm-SP. Furthermore, Hm-SP showed neuroprotective activity in 6-hydroxydopamine-induced neurotoxicity on SH-SY5Y cells by modulation of the mitochondria transmembrane potential and reducing Caspase 3 activity. In addition, Hm-SP demonstrates low antioxidant potential and did not induce significant cytotoxic effects or changes in the cell proliferation on Balb/c 3T3 mouse fibroblast cell-line. In summary, our data suggest that Hm-SP shows antimicrobial, anticancer and neuprotective activities.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSouza, R. B., Frota, A. F., Silva, J., Alves, C., Neugebauer, A. Z., Pinteus, S., Rodrigues, J., Cordeiro, E., de Almeida, R. R., Pedrosa, R., & Benevides, N. (2018). In vitro activities of kappa-carrageenan isolated from red marine alga Hypnea musciformis: Antimicrobial, anticancer and neuroprotective potential. International journal of biological macromolecules, 112, 1248–1256. https://doi.org/10.1016/j.ijbiomac.2018.02.029pt_PT
dc.identifier.doi10.1016/j.ijbiomac.2018.02.029pt_PT
dc.identifier.issn0141--8130
dc.identifier.urihttp://hdl.handle.net/10400.8/4993
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.titleIn vitro activities of kappa-carrageenan isolated from red marine alga Hypnea musciformis: Antimicrobial, anticancer and neuroprotective potentialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMAR%2F04292%2F2013/PT
oaire.citation.endPage1256pt_PT
oaire.citation.startPage1248pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume112pt_PT
oaire.fundingStream5876
person.familyNameSilva
person.familyNameAlves
person.familyNamePinteus
person.familyNamePedrosa
person.givenNameJoana
person.givenNameCelso
person.givenNameSusete
person.givenNameRui
person.identifier98885
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person.identifier.ciencia-id3817-33DE-919E
person.identifier.orcid0000-0003-1224-1699
person.identifier.orcid0000-0003-1581-2127
person.identifier.orcid0000-0002-3290-3111
person.identifier.orcid0000-0003-0970-0575
person.identifier.ridB-3366-2017
person.identifier.ridB-4815-2015
person.identifier.scopus-author-id56370819800
person.identifier.scopus-author-id55654969100
person.identifier.scopus-author-id55655328300
person.identifier.scopus-author-id7005010300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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