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Undaria pinnatifida (U. pinnatifida) bioactivity: Antioxidant, gastro-intestinal motility, cholesterol biosynthesis and liver cell lines proteome

2021Journal article Open access
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dc.contributor.authorPedro, Bernardo
dc.contributor.authorGuedes, Laura
dc.contributor.authorAndré, Rebeca
dc.contributor.authorGaspar, Helena
dc.contributor.authorVaz, Pedro
dc.contributor.authorAscensão, Lia
dc.contributor.authorMelo, Ricardo
dc.contributor.authorSerralheiro, Maria Luisa
dc.date.accessioned2022-08-22T12:49:01Z
dc.date.available2022-08-22T12:49:01Z
dc.date.issued2021
dc.description.abstractUndaria pinnatifida is a brown alga, largely used as food in oriental countries. The purpose of this work was to analyze several bioactivities that might be present in different food preparations, relating them with the compounds present in the extracts. Aqueous extracts cooked, like a soup, as well as used in a salad, by simulating U. pinnatifida digestion with pancreatin were prepared. The soup preparation had anti-acetylcholinesterase activity as well as 3-hydroxy3-methyl-glutaryl coenzyme A reductase inhibition capacity, the use of 1 mg/mL, for both enzymes, caused 50% enzyme activity inhibition. The extracts produced changes in HepG2 cell proteome, mainly in the 148 kDa proteins. U. pinnatifida in salads hardly released phlorotannins to the digestive tract. The in vitro studies suggested that a soup prepared from this seaweed could deliver bioactive compounds, phlorotannins and small peptides that may facilitate the gastro-intestinal motility and reduce the cholesterol biosynthesis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBernardo Pedro, Laura Guedes, Rebeca André, Helena Gaspar, Pedro Vaz, Lia Ascensão, Ricardo Melo, Maria Luísa Serralheiro, Undaria pinnatifida (U. pinnatifida) bioactivity: Antioxidant, gastro-intestinal motility, cholesterol biosynthesis and liver cell lines proteome, Journal of Functional Foods, Volume 83, 2021, 104567, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104567pt_PT
dc.identifier.doi10.1016/j.jff.2021.104567pt_PT
dc.identifier.issn1756-4646
dc.identifier.urihttp://hdl.handle.net/10400.8/7567
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationBiosystems and Integrative Sciences Institute
dc.relationBiosystems and Integrative Sciences Institute
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.relationMolecules for health: cholesterol absorption and transporter proteins expression under the effect of bioactive molecules
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1756464621002164pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectUndaria pinnatifidapt_PT
dc.subjectAcetylcholinesterasept_PT
dc.subjectHMGRpt_PT
dc.subjectLC-HRMS/MSpt_PT
dc.subjectPhlorotannins, small peptidespt_PT
dc.subjectProteomept_PT
dc.titleUndaria pinnatifida (U. pinnatifida) bioactivity: Antioxidant, gastro-intestinal motility, cholesterol biosynthesis and liver cell lines proteomept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMolecules for health: cholesterol absorption and transporter proteins expression under the effect of bioactive molecules
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oaire.citation.titleJournal of Functional Foodspt_PT
oaire.citation.volume83pt_PT
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person.familyNameAndré
person.familyNameGuerreiro Galla Gaspar
person.familyNameAscensão
person.familyNameSerralheiro
person.givenNameRebeca
person.givenNameHelena Margarida
person.givenNameLia Maria Pereira
person.givenNameMaria Luisa
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