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Optimization of Scaffolds in Alginate for Biofabrication by Genetic Algorithms

2009-08Conference paper Open access
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.fosCiências Naturais::Ciências da Computação e da Informação
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorRezende, Rodrigo
dc.contributor.authorRezende, Mylene
dc.contributor.authorBártolo, Paulo
dc.contributor.authorMendes, Ausenda
dc.contributor.authorFilho, Rubens Maciel
dc.contributor.authorBartolo, Paulo
dc.contributor.authorMendes, Ausenda
dc.date.accessioned2025-04-14T15:40:49Z
dc.date.available2025-04-14T15:40:49Z
dc.date.issued2009-08
dc.description10th International Symposium on Process Systems Engineering - PSE 2009
dc.description.abstractWith an increasing in the rate of transplants due to damaged or affected tissues or organs by accidents or diseases and also by the aging of the population in many countries as Brazil, have motivated the research of some novel and alternative ways focused on restoring and replacing tissues. Biofabrication by means of Rapid Prototyping techniques can help in the fashioning and final production of scaffolds devoted to support and stimulate the growth of new tissues. For soft tissues, a biomaterial known as Alginate has been studied and used as raw-material for scaffolds fabrication. A scaffold must guarantee good strength and stiffness at the same time the material degrades gradually. In this work, a single mathematical model experimentally obtained that describes an interesting mechanical behavior of the degradation of alginated-scaffolds is developed. The optimization process scheme using Genetic Algorithms to maximize the elastic modulus and therefore to aid the design of scaffolds in alginate is proposed. The optimization is very welcome to tissue engineering and Biofabrication.eng
dc.identifier.citationRezende, R. A., Rezende, M. C. A. F., Bártolo, P., Mendes, A., & Filho, R. M. (2009). Optimization of scaffolds in alginate for biofabrication by genetic algorithms. Computer Aided Chemical Engineering, 1935-1940. https://doi.org/10.1016/s1570-7946(09)70713-8.
dc.identifier.doi10.1016/s1570-7946(09)70713-8
dc.identifier.isbn9780444534354
dc.identifier.issn1570-7946
dc.identifier.urihttp://hdl.handle.net/10400.8/12797
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.hasversionhttps://shop.elsevier.com/books/10th-international-symposium-on-process-systems-engineering-pse2009/de-brito-alves/978-0-444-53435-4
dc.relation.ispartofComputer Aided Chemical Engineering
dc.relation.ispartof10th International Symposium on Process Systems Engineering: Part A
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGenetic Algorithms (GAs))
dc.subjectScaffolds
dc.subjectBiofabrication
dc.subjectTissue Engineering
dc.subjectAlginate
dc.titleOptimization of Scaffolds in Alginate for Biofabrication by Genetic Algorithmseng
dc.typeconference paper
dspace.entity.typePublication
oaire.citation.conferenceDate2009-08
oaire.citation.conferencePlaceSalvador-Bahia, Brazil
oaire.citation.endPage1940
oaire.citation.startPage1935
oaire.citation.titleComputer Aided Chemical Engineering
oaire.citation.volume27
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBartolo
person.familyNameMendes
person.givenNamePaulo
person.givenNameAusenda
person.identifier203086
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0003-3683-726X
person.identifier.orcid0000-0003-3004-8972
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id6603353041
person.identifier.scopus-author-id7102443940
relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
relation.isAuthorOfPublication5ac3b700-95c6-4782-861a-deea8e449a7c
relation.isAuthorOfPublication.latestForDiscoveryab44d1ae-46d0-45c2-b19f-200024b5a990

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With an increasing in the rate of transplants due to damaged or affected tissues or organs by accidents or diseases and also by the aging of the population in many countries as Brazil, have motivated the research of some novel and alternative ways focused on restoring and replacing tissues. Biofabrication by means of Rapid Prototyping techniques can help in the fashioning and final production of scaffolds devoted to support and stimulate the growth of new tissues. For soft tissues, a biomaterial known as Alginate has been studied and used as raw-material for scaffolds fabrication. A scaffold must guarantee good strength and stiffness at the same time the material degrades gradually. In this work, a single mathematical model experimentally obtained that describes an interesting mechanical behavior of the degradation of alginated-scaffolds is developed. The optimization process scheme using Genetic Algorithms to maximize the elastic modulus and therefore to aid the design of scaffolds in alginate is proposed. The optimization is very welcome to tissue engineering and Biofabrication.
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