A carregar...
Publicação
Optimization of Scaffolds in Alginate for Biofabrication by Genetic Algorithms
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| With an increasing in the rate of transplants due to damaged or affected tissues or organs by accidents or diseases and also by the aging of the population in many countries as Brazil, have motivated the research of some novel and alternative ways focused on restoring and replacing tissues. Biofabrication by means of Rapid Prototyping techniques can help in the fashioning and final production of scaffolds devoted to support and stimulate the growth of new tissues. For soft tissues, a biomaterial known as Alginate has been studied and used as raw-material for scaffolds fabrication. A scaffold must guarantee good strength and stiffness at the same time the material degrades gradually. In this work, a single mathematical model experimentally obtained that describes an interesting mechanical behavior of the degradation of alginated-scaffolds is developed. The optimization process scheme using Genetic Algorithms to maximize the elastic modulus and therefore to aid the design of scaffolds in alginate is proposed. The optimization is very welcome to tissue engineering and Biofabrication. | 467.3 KB | Adobe PDF |
Orientador(es)
Resumo(s)
With an increasing in the rate of transplants due to damaged or affected tissues or organs by accidents or diseases and also by the aging of the population in many countries as Brazil, have motivated the research of some novel and alternative ways focused on restoring and replacing tissues. Biofabrication by means of Rapid Prototyping techniques can help in the fashioning and final production of scaffolds devoted to support and stimulate the growth of new tissues. For soft tissues, a biomaterial known as Alginate has been studied and used as raw-material for scaffolds fabrication. A scaffold must guarantee good strength and stiffness at the same time the material degrades gradually. In this work, a single mathematical model experimentally obtained that describes an interesting mechanical behavior of the degradation of alginated-scaffolds is developed. The optimization process scheme using Genetic Algorithms to maximize the elastic modulus and therefore to aid the design of scaffolds in alginate is proposed. The optimization is very welcome to tissue engineering and Biofabrication.
Descrição
10th International Symposium on Process Systems Engineering - PSE 2009
Palavras-chave
Genetic Algorithms (GAs)) Scaffolds Biofabrication Tissue Engineering Alginate
Contexto Educativo
Citação
Rezende, R. A., Rezende, M. C. A. F., Bártolo, P., Mendes, A., & Filho, R. M. (2009). Optimization of scaffolds in alginate for biofabrication by genetic algorithms. Computer Aided Chemical Engineering, 1935-1940. https://doi.org/10.1016/s1570-7946(09)70713-8.
Editora
Elsevier