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Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012–2015)

2019-01-09Journal article Open access
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dc.contributor.authorSilva-Costa, Catarina
dc.contributor.authorBrito, Maria J.
dc.contributor.authorAguiar, Sandra I.
dc.contributor.authorLopes, Joana P.
dc.contributor.authorRamirez, Mário
dc.contributor.authorMelo-Cristino, José
dc.date.accessioned2019-04-12T15:53:33Z
dc.date.available2019-04-12T15:53:33Z
dc.date.issued2019-01-09
dc.descriptionAcknowledgements: This work was partly supported by Fundação para a Ciência e a Tecnologia, Portugal (PTDC/DTPEPI/1555/2014), LISBOA-01-0145-EDER-007391, project cofunded by FEDER, through POR Lisboa 2020 - Programa Operacional Regional de Lisboa, PORTUGAL 2020 and Fundação para a Ciência e a Tecnologia, and an unrestricted Investigator initiated project from Pfzer. Te funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.description.abstractWe evaluated the impact of continued 13-valent pneumococcal conjugate vaccine (PCV13) use in the private market (uptake of 61%) in pediatric invasive pneumococcal disease (pIPD) in Portugal (2012–2015). The most frequently detected serotypes were: 3 (n = 32, 13.8%), 14 (n = 23, 9.9%), 1 (n = 23, 9.9%), 7F (n = 15, 6.4%), 19A (n = 13, 5.6%), 6B and 15B/C (both n = 12, 5.2%), and 24F, 10A and 12B (all with n = 10, 4.3%). Taken together, non-PCV13 serotypes were responsible for 42.2% of pIPD with a known serotype. The use of PCR to detect and serotype pneumococci in both pleural and cerebrospinal fluid samples contributed to 18.1% (n = 47) of all pIPD. Serotype 3 was mostly detected by PCR (n = 21/32, 65.6%) and resulted from a relevant number of vaccine failures. The incidence of pIPD varied in the different age groups but without a clear trend. There were no obvious declines of the incidence of pIPD due to serotypes included in any of the PCVs, and PCV13 serotypes still accounted for the majority of pIPD (57.8%). Our study indicates that a higher vaccination uptake may be necessary to realize the full benefits of PCVs, even after 15 years of moderate use, and highlights the importance of using molecular methods in pIPD surveillance, since these can lead to substantially increased case ascertainment and identification of particular serotypes as causes of pIPD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1038/s41598-018-36799-xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.8/3905
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationThe changing pneumococci: adapting to vaccination and transitioning between colonization and disease
dc.titleDominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012–2015)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe changing pneumococci: adapting to vaccination and transitioning between colonization and disease
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-EPI%2F1555%2F2014/PT
oaire.citation.titleScientific Reportspt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationb3acc9d4-5783-4145-a675-917cd01a4822
relation.isProjectOfPublication.latestForDiscoveryb3acc9d4-5783-4145-a675-917cd01a4822

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