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Neural Markers of Neuropathic Pain Associated with Maladaptive Plasticity in Spinal Cord Injury

2015-04-28Journal article Restricted access
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datacite.subject.fosEngenharia e Tecnologia
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosCiências Naturais::Matemáticas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorPascoal-Faria, Paula
dc.contributor.authorYalcin, Nilufer
dc.contributor.authorFregni, Felipe
dc.date.accessioned2025-07-14T14:46:22Z
dc.date.available2025-07-14T14:46:22Z
dc.date.issued2015-04-28
dc.description.abstractObjectives: Given the potential use of neural markers for the development of novel treatments in spinal cord pain, we aimed to characterize the most effective neural markers of neuropathic pain following spinal cord injury (SCI). Methods: A systematic PubMed review was conducted, compiling studies that were published prior to April, 2014 that examined neural markers associated with neuropathic pain after SCI using electrophysiological and neuroimaging techniques. Results: We identified 6 studies: Four using electroencephalogram (EEG); 1 using magnetic resonance imaging (MRI) and FDG-PET (positron emission tomography); and 1 using MR spectroscopy. The EEG recordings suggested a reduction in alpha EEG peak frequency activity in the frontal regions of SCI patients with neuropathic pain. The MRI scans showed volume loss, primarily in the gray matter of the left dorsolateral prefrontal cortex, and by FDG-PET, hypometabolism in the medial prefrontal cortex was observed in SCI patients with neuropathic pain compared with healthy subjects. In the MR spectroscopy findings, the presence of pain was associated with changes in the prefrontal cortex and anterior cingulate cortex. Conclusions: When analyzed together, the results of these studies seem to point out to a common marker of pain in SCI characterized by decreased cortical activity in frontal areas and possibly increased subcortical activity. These results may contribute to planning further mechanistic studies as to better understand the mechanisms by which neuropathic pain is modulated in patients with SCI as well as clinical studies investigating best responders of treatment.eng
dc.description.sponsorshipThis study was supported by a grant from the Department of Education, NIDRR H133N110010 (SCI-Model Systems). Paula Pascoal-Faria acknowledges the support of the Strategic Project (PEST-OE/EME/UI4044/2013) funded by the Portuguese Foundation for Science and Technology and also the support of the European Commission through the Marie Curie Project “International Research Exchange for Biomedical Devices Design and Prototyping” “IREBID”.
dc.identifier.citationPascoal-Faria P, Yalcin N, Fregni F. Neural markers of neuropathic pain associated with maladaptive plasticity in spinal cord injury. Pain Pract. 2015 Apr;15(4):371-7. doi: 10.1111/papr.12237.
dc.identifier.doi10.1111/papr.12237
dc.identifier.issn1530-7085
dc.identifier.issn1533-2500
dc.identifier.urihttp://hdl.handle.net/10400.8/13630
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relationStrategic Project - UI 4044 - 2013-2014
dc.relation.hasversionhttps://onlinelibrary.wiley.com/doi/full/10.1111/papr.12237
dc.relation.ispartofPain Practice
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNeural markers
dc.subjectNeuropathic pain
dc.subjectNeuroplasticity
dc.subjectPain
dc.subjectSpinal cord injury
dc.titleNeural Markers of Neuropathic Pain Associated with Maladaptive Plasticity in Spinal Cord Injuryeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 4044 - 2013-2014
oaire.awardURIhttp://hdl.handle.net/10400.8/13452
oaire.citation.endPage377
oaire.citation.issue4
oaire.citation.startPage371
oaire.citation.titlePain Practice
oaire.citation.volume15
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePascoal-Faria
person.givenNamePaula
person.identifier.ciencia-idE01D-874A-4145
person.identifier.orcid0000-0003-1474-9496
relation.isAuthorOfPublicationebb27133-d9ce-4f58-a4ca-f75a786bbc2e
relation.isAuthorOfPublication.latestForDiscoveryebb27133-d9ce-4f58-a4ca-f75a786bbc2e
relation.isProjectOfPublicationf02b0b18-7e69-4879-a8cc-74cd2f9cbc44
relation.isProjectOfPublication.latestForDiscoveryf02b0b18-7e69-4879-a8cc-74cd2f9cbc44

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