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Toward Integrative Biomechanical Models of Osteochondral Tissues: A Multilayered Perspective

2025-06-13Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosEngenharia e Tecnologia
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorFilipe Ramos Cardoso da Silva, Bruna
dc.contributor.authorMarco Domingos
dc.contributor.authorAmado, Sandra
dc.contributor.authorDias, Juliana
dc.contributor.authorPascoal-Faria, Paula
dc.contributor.authorAna C. Maurício
dc.contributor.authorAlves, Nuno
dc.date.accessioned2025-08-04T11:04:55Z
dc.date.available2025-08-04T11:04:55Z
dc.date.issued2025-06-13
dc.descriptionArticle number - 649
dc.descriptionThis article belongs to the Section Biomechanics and Sports Medicine
dc.description.abstractUnderstanding the complex mechanical behavior of osteochondral tissues in silico is essential for improving experimental models and advancing research in joint health and degeneration. This review provides a comprehensive analysis of the constitutive models currently used to represent the different layers of the osteochondral region, from articular cartilage to subchondral bone, including intermediate regions such as the tidemark and the calcified cartilage layer. Each layer exhibits unique structural and mechanical properties, necessitating a layer-specific modeling approach. Through critical comparison of existing mathematical models, the viscoelastic model is suggested as a pragmatic starting point for modeling articular cartilage zones, the tidemark, and the calcified cartilage layer, as it captures essential time-dependent behaviors such as creep and stress relaxation while ensuring computational efficiency for initial coupling studies. On the other hand, a linear elastic model was identified as an optimal starting point for both the subchondral bone plate and the subchondral trabecular bone, reflecting their dense and stiff nature, and providing a coherent framework for early-stage multilayer integration. This layered modeling approach enables the development of physiologically coherent and computationally efficient representations of osteochondral region modeling. Furthermore, by establishing a layer-specific modeling approach, this review paves the way for modular in silico simulations through the coupling of computational models. Such an integrative framework supports scaffold design, in vitro experimentation, preclinical validation, and the mechanobiological exploration of osteochondral degeneration and repair. These efforts are essential for deepening our understanding of tissue responses under both physiological and pathological conditions. Ultimately, this work provides a robust theoretical foundation for future in silico and in vitro studies aimed at advancing osteochondral tissue regeneration strategies.eng
dc.description.sponsorshipThe authors declare that financial support was received for the research, authorship, and/or publication of this article. The Fundação para a Ciência e Tecnologia (FCT)—Portugal and the Centro2020—Portugal funded this work through projects OptiBioScaffold (PTDC/EME-SIS/4446/2020), InnovaBIOMAS (2022.10564. PTDC), CDRSP (UIDB/04044/2020 and UIDP/04044/2020), and Associate Laboratory (ARISE LA/P/0112/2020).
dc.identifier.citationSilva, B.; Domingos, M.; Amado, S.; R. Dias, J.; Pascoal-Faria, P.; Maurício, A.C.; Alves, N. Toward Integrative Biomechanical Models of Osteochondral Tissues: A Multilayered Perspective. Bioengineering 2025, 12, 649. https://doi.org/10.3390/ bioengineering12060649
dc.identifier.doi10.3390/bioengineering12060649
dc.identifier.issn2306-5354
dc.identifier.urihttp://hdl.handle.net/10400.8/13854
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationOptimised additive biomanufacturing system to produce hierarchical multi-tissue scaffolds for the treatment of joint diseases
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationAdvanced Production and Intelligent Systems
dc.relation.hasversionhttps://www.mdpi.com/2306-5354/12/6/649
dc.relation.ispartofBioengineering
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectJoint tissues
dc.subjectOsteochondral modeling
dc.subjectArticular cartilage
dc.subjectTidemark
dc.subjectCalcified cartilage
dc.subjectSubchondral bone
dc.subjectTrabecular bone
dc.subjectConstitutive models
dc.titleToward Integrative Biomechanical Models of Osteochondral Tissues: A Multilayered Perspectiveeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleOptimised additive biomanufacturing system to produce hierarchical multi-tissue scaffolds for the treatment of joint diseases
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleAdvanced Production and Intelligent Systems
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEME-SIS%2F4446%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0112%2F2020/PT
oaire.citation.issue6
oaire.citation.titleBioengineering
oaire.citation.volume12
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFilipe Ramos Cardoso da Silva
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person.familyNamePascoal-Faria
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person.givenNameBruna
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person.identifier.ridO-6988-2016
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person.identifier.scopus-author-id16038616600
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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