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Four-dimensional (bio-)printing: A review on stimuli-responsive mechanisms and their biomedical suitability

2020Journal article Open access
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dc.contributor.authorMorouço, Pedro
dc.contributor.authorAzimi, Bahared
dc.contributor.authorMilazzo, Mario
dc.contributor.authorMokhtari, Fatemeh
dc.contributor.authorFernandes, Cristiana
dc.contributor.authorReis, Diana
dc.contributor.authorDanti, Serena
dc.date.accessioned2023-04-19T10:46:36Z
dc.date.available2023-04-19T10:46:36Z
dc.date.issued2020
dc.descriptionS.D. and B.A. acknowledge NANO-SPARKS project (MISTI funds, MIT-UNIPI 2016). M.M. was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement COLLHEAR no. 794614.pt_PT
dc.description.abstractThe applications of tissue engineered constructs have witnessed great advances in the last few years, as advanced fabrication techniques have enabled promising approaches to develop structures and devices for biomedical uses. (Bio-)printing, including both plain material and cell/material printing, o ers remarkable advantages and versatility to produce multilateral and cell-laden tissue constructs; however, it has often revealed to be insu cient to fulfill clinical needs. Indeed, three-dimensional (3D) (bio-)printing does not provide one critical element, fundamental to mimic native live tissues, i.e., the ability to change shape/properties with time to respond to microenvironmental stimuli in a personalized manner. This capability is in charge of the so-called “smart materials”; thus, 3D(bio-)printing these biomaterials is a possible way to reach four-dimensional (4D) (bio-)printing. We present a comprehensive review on stimuli-responsive materials to produce scaffolds and constructs via additive manufacturing techniques, aiming to obtain constructs that closely mimic the dynamics of native tissues. Our work deploys the advantages and drawbacks of the mechanisms used to produce stimuli-responsive constructs, using a classification based on the target stimulus: humidity, temperature, electricity, magnetism, light, pH, among others. A deep understanding of biomaterial properties, the scaffolding technologies, and the implant site microenvironment would help the design of innovative devices suitable and valuable for many biomedical applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMorouço, P.; Azimi, B.; Milazzo, M.; Mokhtari, F.; Fernandes, C.; Reis, D.; Danti, S. Four-Dimensional (Bio-)printing: A Review on Stimuli-Responsive Mechanisms and Their Biomedical Suitability. Appl. Sci. 2020, 10, 9143. https://doi.org/10.3390/app10249143pt_PT
dc.identifier.doi10.3390/app10249143pt_PT
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.8/8413
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation3D printed COLLagen type I-Hydroxyapatite prostheses for the middle EAR
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/10/24/9143pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdditive manufacturingpt_PT
dc.subjectTissue engineeringpt_PT
dc.subjectSmart materialspt_PT
dc.subjectHydrogelspt_PT
dc.subjectBiofabricationpt_PT
dc.titleFour-dimensional (bio-)printing: A review on stimuli-responsive mechanisms and their biomedical suitabilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitle3D printed COLLagen type I-Hydroxyapatite prostheses for the middle EAR
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/794614/EU
oaire.citation.issue24pt_PT
oaire.citation.titleApplied Sciencespt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamH2020
person.familyNameMorouço
person.familyNameMilazzo
person.familyNameMokhtari
person.familyNameFernandes
person.familyNameDanti
person.givenNamePedro
person.givenNameMario
person.givenNameFatemeh
person.givenNameCristiana Henriques
person.givenNameSerena
person.identifier435983
person.identifier715026
person.identifier1493244
person.identifier1239776
person.identifier.ciencia-idF619-3996-742A
person.identifier.ciencia-id0C18-D3D1-D625
person.identifier.orcid0000-0002-5956-9790
person.identifier.orcid0000-0001-8429-5544
person.identifier.orcid0000-0003-0102-5958
person.identifier.orcid0000-0001-6371-800X
person.identifier.orcid0000-0002-8155-8537
person.identifier.ridK-9545-2013
person.identifier.ridF-1164-2019
person.identifier.ridN-2375-2015
person.identifier.scopus-author-id24339135400
person.identifier.scopus-author-id56073318800
person.identifier.scopus-author-id55861178900
person.identifier.scopus-author-id11239215400
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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