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Rubella antibodies in cord blood sera in Portugal: association with maternal age and vaccination status

2018-02-20Journal article Open access
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dc.contributor.authorFrade, J.
dc.contributor.authorNunes, C.
dc.contributor.authorMesquita, J. R.
dc.contributor.authorNascimento, M. São José
dc.contributor.authorGonçalves, G.
dc.date.accessioned2025-07-17T13:22:11Z
dc.date.available2025-07-17T13:22:11Z
dc.date.issued2018-02-20
dc.description.abstractThis study evaluated the impact of maternal vaccination against rubella on the levels of specific rubella IgG (rIgG) in 198 newborn cord sera samples. Detailed maternal vaccination data were available. Specific rIgG was measured using a commercial enzyme immunoassay. Most mothers (78.8%) had been vaccinated against rubella at least once in their lives. In 15 (7.6%) cord sera samples, the concentration of specific rIgG was below 11 IU/ml, which was classified as seronegative. Statistical analysis using multiple logistic regression (n = 198) showed that newborns of mothers born between 1986 and 1995, and those born to unvaccinated mothers, were more likely to be seronegative (odds ratio (ORs) 5.2 and 4.9, respectively, adjusted for sex and gestational age). For vaccinated mothers (n = 156), those born between 1986 and 1995 were more likely to have seronegative newborns (OR 11.5 adjusting for sex, gestational age and time since last vaccination). Mothers of the 15 (7.6%) seronegative newborns might have been susceptible to rubella during pregnancy. Checking the vaccination status therefore recommended.eng
dc.identifier.citationFrade J, Nunes C, Mesquita JR, São José Nascimento M, Gonçalves G. Rubella antibodies in cord blood sera in Portugal: association with maternal age and vaccination status. Epidemiology and Infection. 2018;146(5):600-605. doi:10.1017/S0950268818000237
dc.identifier.doi10.1017/s0950268818000237
dc.identifier.issn0950-2688
dc.identifier.issn1469-4409
dc.identifier.urihttp://hdl.handle.net/10400.8/13699
dc.language.isoeng
dc.peerreviewedyes
dc.publisherCambridge University Press (CUP)
dc.relation.hasversionhttps://www.cambridge.org/core/journals/epidemiology-and-infection/article/rubella-antibodies-in-cord-blood-sera-in-portugal-association-with-maternal-age-and-vaccination-status/
dc.relation.ispartofEpidemiology and Infection
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectImmunisation (vaccination)
dc.subjectMMR vaccination
dc.subjectrubella
dc.subjectserology
dc.titleRubella antibodies in cord blood sera in Portugal: association with maternal age and vaccination statuseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage605
oaire.citation.issue5
oaire.citation.startPage600
oaire.citation.titleEpidemiology and Infection
oaire.citation.volume146
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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