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Use of Lipid Vesicles for Revealing the Potential Contribution of Cytochrome C in the Metabolism of Environmental Toxicants

2022-06-29Comunicação em conferência Acesso aberto
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg11:Cidades e Comunidades Sustentáveis
dc.contributor.authorLopes, João M.
dc.contributor.authorMarques-da-Silva, Dorinda
dc.contributor.authorVideira, Paula A.
dc.contributor.authorLagoa, Ricardo
dc.date.accessioned2026-03-16T12:48:21Z
dc.date.available2026-03-16T12:48:21Z
dc.date.issued2022-06-29
dc.descriptionArticle number - 6
dc.descriptionThis article belongs to the Proceedings of Biosystems in Toxicology and Pharmacology — Current Challenges.
dc.descriptionPresented at the Biosystems in Toxicology and Pharmacology—Current Challenges, 8–9 September 2022, Online; Available online: https://bitap.sciforum.net/.
dc.description.abstractCytochrome c (Cc) is well-known as an electron carrier at mitochondria but can also catalyze peroxidase-like reactions. Although the reported catalytic abilities are low, the role of Cc in transforming environmental toxicants requires additional studies. We employed cardiolipin vesicles to stimulate the enzymatic activity of Cc and tested the catalytic system towards the dye methyl orange and the polycyclic aromatic hydrocarbons (PAHs) benzo[b]fluoranthene and benzo[a]pyrene. The results showed that cardiolipin-containing vesicles promoted dye decolorization and the oxidation of both PAHs by Cc, indicating that lipid membranes can be useful to further investigate Cc–mediated metabolism of toxicants.eng
dc.description.sponsorshipThis research was funded by Fundação para a Ciência e Tecnologia (FCT—Portugal) through the research project PTDC/BIA-MIB/31864/2017. It was also funded by FCT—Portugal in the scope of the unit projects UIDP/04378/2020 and UIDB/04378/2020 (UCIBIO), LA/P/0140/2020 (i4HB), LA/P/0045/2020 (ALiCE), UIDB/50020/2020 and UIDP/50020/2020 (LSRE-LCM).
dc.identifier.citationLopes, J. M., Marques-da-Silva, D., Videira, P. A., & Lagoa, R. (2022). Use of Lipid Vesicles for Revealing the Potential Contribution of Cytochrome C in the Metabolism of Environmental Toxicants. Medical Sciences Forum, 11(1), 6. https://doi.org/10.3390/BiTaP-12782
dc.identifier.doi10.3390/bitap-12782
dc.identifier.eissn2673-9992
dc.identifier.urihttp://hdl.handle.net/10400.8/15879
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationInstitute for Health and Bioeconomy
dc.relation.hasversionhttps://www.mdpi.com/2673-9992/11/1/6
dc.relation.ispartofBiosystems in Toxicology and Pharmacology—Current Challenges
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectazo dye
dc.subjectpseudo-peroxidase
dc.subjectphospholipid
dc.subjectenvironmental toxicology
dc.subjectbiocatalytic systems
dc.titleUse of Lipid Vesicles for Revealing the Potential Contribution of Cytochrome C in the Metabolism of Environmental Toxicantseng
dc.typeconference paper
dspace.entity.typePublication
oaire.awardNumberPTDC/BIA-MIB/31864/2017
oaire.awardNumberUIDP/04378/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberLA/P/0140/2020
oaire.awardTitleMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIB%2F31864%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/13764
oaire.citation.conferenceDate2022-09
oaire.citation.endPage4
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.titleMedical Sciences Forum
oaire.citation.volume11
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLopes
person.familyNameMarques da Silva
person.familyNameLagoa
person.givenNameJoão
person.givenNameDorinda
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0003-4374-6577
person.identifier.orcid0000-0003-0460-5421
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id23051352300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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