Repository logo
 
Publication

Marine endophytic fungi associated with Halopteris scoparia (Linnaeus) Sauvageau as producers of bioactive secondary metabolites with potential dermocosmetic application

2021Journal article Open access
Simple item page
dc.contributor.authorCalado, Maria da Luz
dc.contributor.authorSilva, Joana
dc.contributor.authorAlves, Celso
dc.contributor.authorSusano, Patrícia
dc.contributor.authorSantos, Débora
dc.contributor.authorAlves, Joana
dc.contributor.authorMartins, Alice
dc.contributor.authorGaspar, Helena
dc.contributor.authorPedrosa, Rui
dc.contributor.authorCampos, Maria Jorge
dc.date.accessioned2021-07-29T14:52:36Z
dc.date.available2021-07-29T14:52:36Z
dc.date.issued2021
dc.descriptionThis work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre and UIDP/Multi/ 04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/2015-LISBOA-01-0145-FEDER016405), and through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250). This work was also funded by the Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (Centro-01-0145-FEDER000018), co-funded by Centro 2020 Programme, Portugal 2020, European Union, through the European Regional Development Fund. Moreover, Joana Silva was financially supported by a grant from FCT (SFRH/BD/103255/2014). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.description.abstractMarine fungi and, particularly, endophytic species have been recognised as one of the most prolific sources of structurally new and diverse bioactive secondary metabolites with multiple biotechnological applications. Despite the increasing number of bioprospecting studies, very few have already evaluated the cosmeceutical potential of marine fungal compounds. Thus, this study focused on a frequent seaweed in the Portuguese coast, Halopteris scoparia, to identify the endophytic marine fungi associated with this host, and assess their ability to biosynthesise secondary metabolites with antioxidative, enzymatic inhibitory (hyaluronidase, collagenase, elastase and tyrosinase), anti-inflammatory, photoprotective, and antimicrobial (Cutibacterium acnes, Staphylococcus epidermidis and Malassezia furfur) activities. The results revealed eight fungal taxa included in the Ascomycota, and in the most representative taxonomic classes in marine ecosystems (Eurotiomycetes, Sordariomycetes and Dothideomycetes). These fungi were reported for the first time in Portugal and in association with H. scoparia, as far as it is known. The screening analyses showed that most of these endophytic fungi were producers of compounds with relevant biological activities, though those biosynthesised by Penicillium sect. Exilicaulis and Aspergillus chevalieri proved to be the most promising ones for being further exploited by dermocosmetic industry. The chemical analysis of the crude extract from an isolate of A. chevalieri revealed the presence of two bioactive compounds, echinulin and neoechinulin A, which might explain the high antioxidant and UV photoprotective capacities exhibited by the extract. These noteworthy results emphasised the importance of screening the secondary metabolites produced by these marine endophytic fungal strains for other potential bioactivities, and the relevance of investing more efforts in understanding the ecology of halo/osmotolerant fungi.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCalado MdL, Silva J, Alves C, Susano P, Santos D, Alves J, et al. (2021) Marine endophytic fungi associated with Halopteris scoparia (Linnaeus) Sauvageau as producers of bioactive secondary metabolites with potential dermocosmetic application. PLoS ONE 16(5): e0250954. https://doi.org/10.1371/journal. pone.0250954 Editor: Branislav T.S ˇpt_PT
dc.identifier.doi10.1371/journal. pone.0250954pt_PT
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.8/5971
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relationNeuroprotective effects of molecules isolated from Bifurcaria bifurcata and Codium tomentosum in an in vitro and in vivo Parkinson Disease model.
dc.relationBiosystems and Integrative Sciences Institute
dc.relationBiosystems and Integrative Sciences Institute
dc.relationPRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250954pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleMarine endophytic fungi associated with Halopteris scoparia (Linnaeus) Sauvageau as producers of bioactive secondary metabolites with potential dermocosmetic applicationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNeuroprotective effects of molecules isolated from Bifurcaria bifurcata and Codium tomentosum in an in vitro and in vivo Parkinson Disease model.
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitlePRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-OUT%2F29250%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F103255%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04046%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04046%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/SAICTPAC%2F0019%2F2015/PT
oaire.citation.titlePlos onept_PT
oaire.citation.volume13pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamPOR_CENTRO
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
person.familyNameJeremias Cardinha do Maio Calado
person.familyNameSilva
person.familyNameAlves
person.familyNameFrederico Susano
person.familyNameAlves
person.familyNameMartins
person.familyNameGuerreiro Galla Gaspar
person.familyNamePedrosa
person.familyNameCampos
person.givenNameMaria da Luz
person.givenNameJoana
person.givenNameCelso
person.givenNamePatrícia
person.givenNameJoana
person.givenNameAlice
person.givenNameHelena Margarida
person.givenNameRui
person.givenNameMaria Jorge
person.identifier98885
person.identifier159091
person.identifierE-6798-2012
person.identifier349272
person.identifier174191
person.identifier.ciencia-idBB10-343C-F401
person.identifier.ciencia-id6317-6F15-BA35
person.identifier.ciencia-id501C-F268-2E60
person.identifier.ciencia-id581E-146A-9945
person.identifier.ciencia-id4C1C-141D-7E29
person.identifier.ciencia-idDA19-728A-9BC8
person.identifier.ciencia-id761C-044C-995B
person.identifier.ciencia-id3817-33DE-919E
person.identifier.ciencia-id2416-7867-2D40
person.identifier.orcid0000-0002-3711-7937
person.identifier.orcid0000-0003-1224-1699
person.identifier.orcid0000-0003-1581-2127
person.identifier.orcid0000-0003-1426-2071
person.identifier.orcid0000-0003-0524-9270
person.identifier.orcid0000-0002-0542-2662
person.identifier.orcid0000-0002-1613-7023
person.identifier.orcid0000-0003-0970-0575
person.identifier.orcid0000-0002-0883-0610
person.identifier.ridB-3366-2017
person.identifier.ridB-4815-2015
person.identifier.ridE-5591-2014
person.identifier.scopus-author-id56370819800
person.identifier.scopus-author-id55654969100
person.identifier.scopus-author-id56013514200
person.identifier.scopus-author-id7003891380
person.identifier.scopus-author-id7005010300
person.identifier.scopus-author-id55767069800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd8778214-1601-4f52-b604-489e92118c08
relation.isAuthorOfPublication23e68f76-0f7a-4f39-9da8-f1a26e2e2cd7
relation.isAuthorOfPublicationba5ab7c2-7474-4ea9-9bf0-ca15fe42809a
relation.isAuthorOfPublicationce96a85c-582d-4a93-817b-0ac227d64e05
relation.isAuthorOfPublication9ff5eb18-16a8-4b52-a0a6-62f920141e9c
relation.isAuthorOfPublication1bc1a00d-0af9-4be5-b19f-ddaf89268517
relation.isAuthorOfPublication580efc75-e17e-4380-ae50-e5bc1d0bc10d
relation.isAuthorOfPublication94496a40-57cf-472f-94e1-5db9d5da78b6
relation.isAuthorOfPublication6d1bf3db-fdba-4bea-b65d-94491f841659
relation.isAuthorOfPublication.latestForDiscovery1bc1a00d-0af9-4be5-b19f-ddaf89268517
relation.isProjectOfPublication26a2e10e-ee41-49ad-9279-4aeaa596b99f
relation.isProjectOfPublication4e599bd2-3733-4520-8d96-9035a23f9e78
relation.isProjectOfPublication059761fa-0273-4f26-b10b-36a381e01984
relation.isProjectOfPublication67482a6d-1f37-4e55-a5f6-6bf03b067106
relation.isProjectOfPublicationa20124dd-fb5c-480a-b543-bb1a7f87c029
relation.isProjectOfPublication.latestForDiscovery67482a6d-1f37-4e55-a5f6-6bf03b067106

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Silva_2021_et al_journal.pone.0250954.pdf
Size:
2.63 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

MARE - Artigos com peer review