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Fabrication of Poly(𝜀-caprolactone) Scaffolds Reinforced with Cellulose Nanofibers, with and without the Addition of Hydroxyapatite Nanoparticles

2016Journal article Open access
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorMorouço, Pedro
dc.contributor.authorBiscaia, Sara
dc.contributor.authorViana, Tânia
dc.contributor.authorFranco, Margarida
dc.contributor.authorPereira Malça, Cândida Maria dos Santos
dc.contributor.authorMateus, Artur
dc.contributor.authorMonteiro de Moura, Carla Sofia
dc.contributor.authorFerreira, Frederico C.
dc.contributor.authorMitchell, Geoffrey
dc.contributor.authorAlves, Nuno M.
dc.date.accessioned2025-06-16T12:36:28Z
dc.date.available2025-06-16T12:36:28Z
dc.date.issued2016
dc.description.abstractBiomaterial properties and controlled architecture of scaffolds are essential features to provide an adequate biological and mechanical support for tissue regeneration, mimicking the ingrowth tissues. In this study, a bioextrusion system was used to produce 3D biodegradable scaffolds with controlled architecture, comprising three types of constructs: (i) poly(𝜀-caprolactone) (PCL) matrix as reference; (ii) PCL-based matrix reinforced with cellulose nanofibers (CNF); and (iii) PCL-based matrix reinforced with CNF and hydroxyapatite nanoparticles (HANP). The effect of the addition and/or combination of CNF and HANP into the polymeric matrix of PCL was investigated, with the effects of the biomaterial composition on the constructs (morphological, thermal, and mechanical performances) being analysed. Scaffolds were produced using a single lay-down pattern of 0/90∘, with the same processing parameters among all constructs being assured. The performed morphological analyses showed a satisfactory distribution of CNF within the polymer matrix and high reliability was obtained among the produced scaffolds. Significant effects on surface wettability and thermal properties were observed, among scaffolds. Regarding the mechanical properties, higher scaffold stiffness in the reinforced scaffolds was obtained. Results from the cytotoxicity assay suggest that all the composite scaffolds presented good biocompatibility.The results of this first study on cellulose and hydroxyapatite reinforced constructs with controlled architecture clearly demonstrate the potential of these 3D composite constructs for cell cultivation with enhanced mechanical properties.por
dc.description.sponsorshipThe research is funded by the Projects References (UID/Multi/04044/2013, BioMaTE: PTDC/EMS-SIS/7032/2014, UID/BIO/04565/2013), iBB H3D Grant (iBB/2015/18), and SFRH/BD/73970/2010 from the Portuguese Foundation for Science and Technology, as well as PORL (LISBOA-01-0145-FEDER-007317) and POR (no. Proj. N. 007317), funded by ERDF Portugal 2020.
dc.identifier.citationMorouço, Pedro, Biscaia, Sara, Viana, Tânia, Franco, Margarida, Malça, Cândida, Mateus, Artur, Moura, Carla, Ferreira, Frederico C., Mitchell, Geoffrey, Alves, Nuno M., Fabrication of Poly(ε-caprolactone) Scaffolds Reinforced with Cellulose Nanofibers, with and without the Addition of Hydroxyapatite Nanoparticles, BioMed Research International, 2016, 1596157, 10 pages, 2016. https://doi.org/10.1155/2016/1596157
dc.identifier.doi10.1155/2016/1596157
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.urihttp://hdl.handle.net/10400.8/13257
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relation.hasversionhttps://onlinelibrary.wiley.com/doi/10.1155/2016/1596157
dc.relation.ispartofBioMed Research International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleFabrication of Poly(𝜀-caprolactone) Scaffolds Reinforced with Cellulose Nanofibers, with and without the Addition of Hydroxyapatite Nanoparticleseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBioMed Research International
oaire.citation.volume2016
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMorouço
person.familyNameBiscaia
person.familyNameViana
person.familyNameFranco
person.familyNamePereira Malça
person.familyNameMateus
person.familyNameMonteiro de Moura
person.givenNamePedro
person.givenNameSara
person.givenNameTânia
person.givenNameMargarida
person.givenNameCândida Maria dos Santos
person.givenNameArtur
person.givenNameCarla Sofia
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