Ridolfia segetum (L.) Moris (Apiaceae) from Portugal: A source of safe antioxidant and anti-inflammatory essential oil

Cabral, C.; Poças Almeida, Juliana; Gonçalves, M.J.; Cavaleiro, C.; Cruz, M.T.; Salgueiro, L.

Publication

Ridolfia segetum (L.) Moris (Apiaceae) from Portugal: A source of safe antioxidant and anti-inflammatory essential oil

2015-03Journal article

datacite.subject.fos	Ciências Naturais::Ciências da Terra e do Ambiente
datacite.subject.fos	Ciências Médicas::Ciências da Saúde
datacite.subject.sdg	15:Proteger a Vida Terrestre
dc.contributor.author	Cabral, C.
dc.contributor.author	Poças Almeida, Juliana
dc.contributor.author	Gonçalves, M.J.
dc.contributor.author	Cavaleiro, C.
dc.contributor.author	Cruz, M.T.
dc.contributor.author	Salgueiro, L.
dc.date.accessioned	2025-07-07T15:00:54Z
dc.date.available	2025-07-07T15:00:54Z
dc.date.issued	2015-03
dc.description
dc.description.abstract	Ridolfia segetum (L.) Moris essential oil was obtained by hydrodistillation and analysed by GC and GC-MS. The antioxidant properties were evaluated through the TBARS assay, and the in vitro anti-inflammatory activity was assessed through inhibition of NO production triggered by the Toll-like receptor 4 (TLR4) agonist, lipopolysaccharide (LPS), in mouse macrophages. Assessment of cell viability was made through a colorimetric assay using MTT on macrophages, keratinocytes, and hepatocytes. The main compounds are α-phellandrene (53.0-63.3%), terpinolene (11.9-8.6%), ß-phellandrene (5.5-6.0%), and dillapiol (1.9-8.0%). The oil demonstrated high antioxidant capacity in the concentrations tested (0.05-0.20. μL/mL) and significantly inhibited NO production without cytotoxicity in concentrations up to 1.25. μL/mL. The plants showed a high essential oil yield, which confers an industrial potential interest. Also, the high content of α-phellandrene (53.0-63.3%) makes it an important natural source of this compound. These results provide evidence of the therapeutic effects of this oil, and suggest that the anti-inflammatory activity in doses without cytotoxicity on mammalian cells, combined with its antioxidant potential and pleasant smell, could be of great value in the development of new phytopharmaceuticals.	eng
dc.description.sponsorship	Acknowledgements This work was funded by FCT–Fundac¸ ão para a Ciência e a Tecnologia under the project PEst-OE/SAU/UI0177/2011 and by the Post-Doc fellowship SFRH/BPD/68481/2010.
dc.identifier.citation	Cabral, Célia & Poças, Juliana & Gonçalves, Maria & Cavaleiro, Carlos & Salgueiro, Ligia. (2015). Ridolfia segetum (L.) Moris (Apiaceae) from Portugal: A source of safe antioxidant and anti-inflammatory essential oil. Industrial Crops and Products. 65. 10.1016/j.indcrop.2014.11.041.
dc.identifier.doi	10.1016/j.indcrop.2014.11.041
dc.identifier.issn	0926-6690
dc.identifier.uri	http://hdl.handle.net/10400.8/13562
dc.language.iso	eng
dc.peerreviewed	yes
dc.publisher	Elsevier
dc.relation	Strategic Project - UI 177 - 2011-2012
dc.relation	THE HISTORY OF PHARMACOGNOSY IN PORTUGAL
dc.relation.hasversion	https://www.sciencedirect.com/science/article/pii/S0926669014007481
dc.relation.ispartof	Industrial Crops and Products
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	Anti-inflammatory activity
dc.subject	Antioxidant activity
dc.subject	Cytotoxicity
dc.subject	Essential oil
dc.subject	Ridolfia segetum
dc.subject	α-Phellandrene
dc.title	Ridolfia segetum (L.) Moris (Apiaceae) from Portugal: A source of safe antioxidant and anti-inflammatory essential oil	eng
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Strategic Project - UI 177 - 2011-2012
oaire.awardTitle	THE HISTORY OF PHARMACOGNOSY IN PORTUGAL
oaire.awardURI	http://hdl.handle.net/10400.8/13560
oaire.awardURI	http://hdl.handle.net/10400.8/13561
oaire.citation.endPage	61
oaire.citation.startPage	56
oaire.citation.title	Industrial Crops and Products
oaire.citation.volume	65
oaire.fundingStream	6817 - DCRRNI ID
oaire.fundingStream	FARH
oaire.version	http://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyName	Poças Almeida
person.givenName	Juliana
person.identifier.orcid	0000-0003-2877-473X
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