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Promotion of Dermal Permeation of Bioactive Compounds Using a Microneedle Device

2022-07-21Comunicação em conferência Acesso aberto
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg11:Cidades e Comunidades Sustentáveis
dc.contributor.authorViolante, Cristiana
dc.contributor.authorLagoa, Ricardo
dc.contributor.authorMarques-da-Silva, Dorinda
dc.date.accessioned2026-03-16T12:41:31Z
dc.date.available2026-03-16T12:41:31Z
dc.date.issued2022-07-21
dc.descriptionArticle number - 4
dc.descriptionThis article belongs to the Proceedings of Biosystems in Toxicology and Pharmacology—Current Challenges.
dc.descriptionPresented at the Biosystems in Toxicology and Pharmacology — Current challenges, 8–9 September 2022, Online; Available online: https://bitap.sciforum.net/
dc.description.abstractSeveral natural bioactive compounds are described for their beneficial effects to skin. Nevertheless, for some compounds, dermal absorption is a challenge, demanding new methods to enhance skin penetration. In this work, pre-treatment with a microneedle device was tested to promote the permeation of caffeine and epicatechin through ex vivo pig skin. The results indicated that the microneedle pre-treatment increased the permeation of both compounds at a similar range. Compared to untreated skin, more than 20% higher amounts of caffeine and epicatechin crossed the treated skin. The data support the application of microneedle systems to promote the dermal delivery of bioactive compounds.eng
dc.description.sponsorshipFunding: This research was funded by FUNDAÇÃO PARA A CIÊNCIA e TECNOLOGIA (FCT—Portugal), grant number PTDC/BIA-MIB/31864/2017 and by LA/P/0045/2020 (ALiCE), UIDB/50020/2020 and UIDP/50020/2020 (LSRE-LCM), funded by national funds through FCT/MCTES (PIDDAC).
dc.identifier.citationViolante, C., Lagoa, R., & Marques-da-Silva, D. (2022). Promotion of Dermal Permeation of Bioactive Compounds Using a Microneedle Device. Medical Sciences Forum, 11(1), 4. https://doi.org/10.3390/BiTaP-12840
dc.identifier.doi10.3390/bitap-12840
dc.identifier.eissn2673-9992
dc.identifier.urihttp://hdl.handle.net/10400.8/15878
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relation.hasversionhttps://www.mdpi.com/2673-9992/11/1/4
dc.relation.ispartofBiosystems in Toxicology and Pharmacology—Current Challenges
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbioactive compounds
dc.subjectcaffeine
dc.subjectepicatechin
dc.subjectskin permeation
dc.subjectmicroneedles
dc.titlePromotion of Dermal Permeation of Bioactive Compounds Using a Microneedle Deviceeng
dc.typeconference paper
dspace.entity.typePublication
oaire.awardNumberPTDC/BIA-MIB/31864/2017
oaire.awardNumberLA/P/0045/2020
oaire.awardNumberUIDB/50020/2020
oaire.awardNumberUIDP/50020/2020
oaire.awardTitleMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
oaire.awardTitleALICE - Associate Laboratory in Chemical Engineering
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIB%2F31864%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0045%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50020%2F2020/PT
oaire.citation.conferenceDate2022-09
oaire.citation.endPage4
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.titleMedical Sciences Forum
oaire.citation.volume11
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameViolante
person.familyNameLagoa
person.familyNameMarques da Silva
person.givenNameCristiana
person.givenNameRicardo
person.givenNameDorinda
person.identifier124357
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0009-0003-6081-0427
person.identifier.orcid0000-0003-2375-6612
person.identifier.orcid0000-0003-0460-5421
person.identifier.scopus-author-id23051352300
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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