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Promotion of Dermal Permeation of Bioactive Compounds Using a Microneedle Device
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Orientador(es)
Resumo(s)
Several natural bioactive compounds are described for their beneficial effects to skin. Nevertheless, for some compounds, dermal absorption is a challenge, demanding new methods to enhance skin penetration. In this work, pre-treatment with a microneedle device was tested to promote the permeation of caffeine and epicatechin through ex vivo pig skin. The results indicated that the microneedle pre-treatment increased the permeation of both compounds at a similar range. Compared to untreated skin, more than 20% higher amounts of caffeine and epicatechin crossed the treated skin. The data support the application of microneedle systems to promote the dermal delivery of bioactive compounds.
Descrição
Article number - 4
This article belongs to the Proceedings of Biosystems in Toxicology and Pharmacology—Current Challenges.
Presented at the Biosystems in Toxicology and Pharmacology — Current challenges, 8–9 September 2022, Online; Available online: https://bitap.sciforum.net/
This article belongs to the Proceedings of Biosystems in Toxicology and Pharmacology—Current Challenges.
Presented at the Biosystems in Toxicology and Pharmacology — Current challenges, 8–9 September 2022, Online; Available online: https://bitap.sciforum.net/
Palavras-chave
bioactive compounds caffeine epicatechin skin permeation microneedles
Contexto Educativo
Citação
Violante, C., Lagoa, R., & Marques-da-Silva, D. (2022). Promotion of Dermal Permeation of Bioactive Compounds Using a Microneedle Device. Medical Sciences Forum, 11(1), 4. https://doi.org/10.3390/BiTaP-12840
Editora
MDPI