Four-Dimensional Bioprinting for Regenerative Medicine: Mechanisms to Induce Shape  Variation and Potential Applications

Morouço, Pedro; Gil, João

Publication

Four-Dimensional Bioprinting for Regenerative Medicine: Mechanisms to Induce Shape Variation and Potential Applications

2019Journal article

dc.contributor.author	Morouço, Pedro
dc.contributor.author	Gil, João
dc.date.accessioned	2023-04-21T15:46:09Z
dc.date.available	2023-04-21T15:46:09Z
dc.date.issued	2019
dc.description.abstract	Regenerative medicine is an exciting field of research, in which significant steps are being taken that are leading to the translation of the technique into clinical practice. In the near future, it is expected that clinicians will have the opportunity to bioprint tissues and organs that closely mimic native human tissues. To do so, imaging of patients must be translated to digital models and then fabricated in a layer-by-layer fashion. The main aim of this review is to elaborate on the possible mechanisms that support four-dimensional bioprinting, as well as provide examples of current and future applications of the technology. This technology, considering time as the fourth dimension, emerged with the aim to develop bioactive functional constructs with programmed stimuli responses. The main idea is to have three-dimensional-printed constructs that are responsive to preplanned stimuli. With this review, the authors aim to provoke creative thinking, highlighting several issues that need to be addressed when reproducing such a complex network as the human body. The authors envision that there are some key features that need to be studied in the near future: printed constructs should be able to respond to different types of stimuli in a timely manner, bioreactors must be developed combining different types of automated stimuli and aiming to replicate the in vivo ecology, and adequate testing procedures must be developed to obtain a proper assessment of the constructs. The effective development of a printed construct that supports tissue maturation according to the anticipated stimuli will significantly advance this promising approach to regenerative medicine.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Morouço, Pedro & Gil, João (2019). Four-Dimensional Bioprinting for Regenerative Medicine: Mechanisms to Induce Shape Variation and Potential Applications. EMJ Innovation, 3(1), 36-43. https://doi.org/10.33590/emjinnov/18-00070	pt_PT
dc.identifier.doi	https://doi.org/10.33590/emjinnov/18-00070	pt_PT
dc.identifier.eissn	2513-8634
dc.identifier.uri	http://hdl.handle.net/10400.8/8443
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	European Medical Group	pt_PT
dc.relation.publisherversion	https://www.emjreviews.com/innovations/article/editors-pick-four-dimensional-bioprinting-for-regenerative-medicine-mechanisms-to-induce-shape-variation-and-potential-applications/	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	pt_PT
dc.title	Four-Dimensional Bioprinting for Regenerative Medicine: Mechanisms to Induce Shape Variation and Potential Applications	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	43	pt_PT
oaire.citation.issue	1	pt_PT
oaire.citation.startPage	36	pt_PT
oaire.citation.title	EMJ Innovation	pt_PT
oaire.citation.volume	3	pt_PT
person.familyName	Morouço
person.familyName	Ferreira Gil
person.givenName	Pedro
person.givenName	João
person.identifier	435983
person.identifier.ciencia-id	F619-3996-742A
person.identifier.ciencia-id	F01F-FDDA-5C66
person.identifier.orcid	0000-0002-5956-9790
person.identifier.orcid	0000-0002-5554-5062
person.identifier.rid	K-9545-2013
person.identifier.scopus-author-id	24339135400
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
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