Repository logo
 
Publication

Metal alginates for polyphenol delivery systems: Studies on crosslinking ions and easy-to-use patches for release of protective flavonoids in skin

2020-09Journal article Open access
Simple item page
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosEngenharia e Tecnologia::Outras Engenharias e Tecnologias
datacite.subject.fosCiências Naturais::Outras Ciências Naturais
datacite.subject.sdg06:Água Potável e Saneamento
datacite.subject.sdg11:Cidades e Comunidades Sustentáveis
datacite.subject.sdg13:Ação Climática
dc.contributor.authorSilva, João
dc.contributor.authorVanat, Pavlo
dc.contributor.authorMarques da Silva, Dorinda
dc.contributor.authorRodrigues, Joaquim Rui
dc.contributor.authorLagoa, Ricardo
dc.date.accessioned2025-09-04T16:57:02Z
dc.date.available2025-09-04T16:57:02Z
dc.date.issued2020-09
dc.descriptionVanat, Pavlo - Scopus ID: 57216206889
dc.description.abstractIncorporation of bioactive natural compounds like polyphenols is an attractive approach for enhanced functionalities of biomaterials. In particular flavonoids have important pharmacological activities, and controlled release systems may be instrumental to realize the full potential of these phytochemicals. Alginate presents interesting attributes for dermal and other biomaterial applications, and studies were carried here to support the development of polyphenol-loaded alginate systems. Studies of capillary viscosity indicated that ionic medium is an effective strategy to modulate the polyelectrolyte effect and viscosity properties of alginates. On gelation, considerable differences were observed between alginate gels produced with Ca2+, Ba2+, Cu2+, Fe2+, Fe3+ and Zn2+ as crosslinkers, especially concerning shrinkage and morphological regularity. Stability assays with different polyphenols in the presence of alginate-gelling cations pointed to the choice of calcium, barium and zinc as safer crosslinkers. Alginate-based films loaded with epicatechin were prepared and the kinetics of release of the flavonoid investigated. The results with calcium, barium and zinc alginate matrices indicated that the release dynamics is dependent on film thicknesses, but also on the crosslinking metal used. On these grounds, an alginate-based system of convenient use was devised, so that flavonoids can be easily loaded at simple point-of-care conditions before dermal application. This epicatechin-loaded patch was tested on an ex-vivo skin model and demonstrated capacity to deliver therapeutically relevant concentrations on skin surface. Moreover, the flavonoid released was not modified and retained full antioxidant bioactivity. The alginate-based system proposed offers a multifunctional approach for flavonoid controllable delivery and protection of skin injured or under risk.eng
dc.description.sponsorshipAuthors acknowledge the support by “Fundação para a Ciência e Tecnologia” (FCT – Portugal) through the research project PTDC/BIAMIB/31864/2017.
dc.identifier.citationJoão Silva, Pavlo Vanat, Dorinda Marques-da-Silva, Joaquim Rui Rodrigues, Ricardo Lagoa, Metal alginates for polyphenol delivery systems: Studies on crosslinking ions and easy-to-use patches for release of protective flavonoids in skin, Bioactive Materials, Volume 5, Issue 3, 2020, Pages 447-457, ISSN 2452-199X, https://doi.org/10.1016/j.bioactmat.2020.03.012.
dc.identifier.doi10.1016/j.bioactmat.2020.03.012
dc.identifier.issn2452-199X
dc.identifier.urihttp://hdl.handle.net/10400.8/13991
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S2452199X20300529?via%3Dihub
dc.relation.ispartofBioactive Materials
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectTopical drug delivery
dc.subjectIntrinsic viscosity
dc.subjectBiopolymer
dc.subjectEpigallocatechin-gallate
dc.subjectAntioxidant dressing
dc.titleMetal alginates for polyphenol delivery systems: Studies on crosslinking ions and easy-to-use patches for release of protective flavonoids in skineng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage457
oaire.citation.issue3
oaire.citation.startPage447
oaire.citation.titleBioactive Materials
oaire.citation.volume5
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSilva
person.familyNameMarques da Silva
person.familyNameRodrigues
person.familyNameLagoa
person.givenNameJoão
person.givenNameDorinda
person.givenNameJoaquim Rui
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id9819-5C0E-48C2
person.identifier.ciencia-id9018-0B83-E2C6
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0002-6139-6841
person.identifier.orcid0000-0003-0460-5421
person.identifier.orcid0000-0002-9756-1124
person.identifier.orcid0000-0003-2375-6612
person.identifier.ridL-4137-2014
person.identifier.scopus-author-id10242931100
person.identifier.scopus-author-id23051352300
relation.isAuthorOfPublicationca7fce54-bbbc-40e8-8816-4b676f3a7c91
relation.isAuthorOfPublication475787c4-cf46-4b3b-96ec-a5278d5cc6f5
relation.isAuthorOfPublication52f6ffb2-43e9-4f78-b414-dbac46f80305
relation.isAuthorOfPublication8a139213-9a89-4bd3-93ee-1e332519f96b
relation.isAuthorOfPublication.latestForDiscoveryca7fce54-bbbc-40e8-8816-4b676f3a7c91

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Metal alginates for polyphenol delivery systems Studies on crosslinking ions and easy-to-use patches for release of protective flavonoids in skin.pdf
Size:
1.72 MB
Format:
Adobe Portable Document Format
Description:
Incorporation of bioactive natural compounds like polyphenols is an attractive approach for enhanced functionalities of biomaterials. In particular flavonoids have important pharmacological activities, and controlled release systems may be instrumental to realize the full potential of these phytochemicals. Alginate presents interesting attributes for dermal and other biomaterial applications, and studies were carried here to support the development of polyphenol-loaded alginate systems. Studies of capillary viscosity indicated that ionic medium is an effective strategy to modulate the polyelectrolyte effect and viscosity properties of alginates. On gelation, considerable differences were observed between alginate gels produced with Ca2+, Ba2+, Cu2+, Fe2+, Fe3+ and Zn2+ as crosslinkers, especially concerning shrinkage and morphological regularity. Stability assays with different polyphenols in the presence of alginate-gelling cations pointed to the choice of calcium, barium and zinc as safer crosslinkers. Alginate-based films loaded with epicatechin were prepared and the kinetics of release of the flavonoid investigated. The results with calcium, barium and zinc alginate matrices indicated that the release dynamics is dependent on film thicknesses, but also on the crosslinking metal used. On these grounds, an alginate-based system of convenient use was devised, so that flavonoids can be easily loaded at simple point-of-care conditions before dermal application. This epicatechin-loaded patch was tested on an ex-vivo skin model and demonstrated capacity to deliver therapeutically relevant concentrations on skin surface. Moreover, the flavonoid released was not modified and retained full antioxidant bioactivity. The alginate-based system proposed offers a multifunctional approach for flavonoid controllable delivery and protection of skin injured or under risk.
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.32 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTG - Artigos em revistas internacionais