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How to correctly estimate the electric field in capacitively coupled systems for tissue engineering: a comparative study

2022Journal article Open access
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dc.contributor.authorMeneses, João
dc.contributor.authorFernandes, Sofia
dc.contributor.authorAlves, Nuno
dc.contributor.authorPascoal-Faria, Paula
dc.contributor.authorMiranda, Pedro Cavaleiro
dc.date.accessioned2023-02-23T15:26:43Z
dc.date.available2023-02-23T15:26:43Z
dc.date.issued2022
dc.description.abstractCapacitively Coupled (CCoupled) electric fields are used to stimulate cell cultures in Tissue Engineering. Knowing the electric field (E-Field) magnitude in the culture medium is fundamental to establish a relationship between stimulus strength and cellular effects. We analysed eight CCoupled studies and sought to corroborate the reported estimates of the E-Field in the culture medium. First, we reviewed the basic physics underlying CCoupled stimulation and delineated three approaches to estimate the E-field. Using these approaches, we found that the reported values were overestimated in five studies, four of which were based on incorrect assumptions. In all studies, insufficient information was provided to reproduce the setup exactly. Creating electrical models of the experimental setup should improve the accuracy of the E-field estimates and enhance reproducibility. For this purpose, we developed a free open-source tool, the E-field Calculator for CCoupled systems, which is available for download from an internet hosting platform.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMeneses, J., Fernandes, S., Alves, N. et al. How to correctly estimate the electric field in capacitively coupled systems for tissue engineering: a comparative study. Sci Rep 12, 11049 (2022). https://doi.org/10.1038/s41598-022-14834-2pt_PT
dc.identifier.doi10.1038/s41598-022-14834-2pt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.8/8157
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNaturept_PT
dc.relationPTDC/EMESIS/32554/2017pt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationInstitute of <biophysics and Biomedical Engineering
dc.relationNumerical Modelling of Mechanical and Electromagnetic Stimulation in Bioreactors and Scaffolds for Tissue Engineering
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-022-14834-2pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleHow to correctly estimate the electric field in capacitively coupled systems for tissue engineering: a comparative studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleInstitute of <biophysics and Biomedical Engineering
oaire.awardTitleNumerical Modelling of Mechanical and Electromagnetic Stimulation in Bioreactors and Scaffolds for Tissue Engineering
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEME-SIS%2F4446%2F2020/PT
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oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume12pt_PT
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oaire.fundingStream6817 - DCRRNI ID
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person.familyNameMeneses
person.familyNameFernandes
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person.familyNamePascoal-Faria
person.familyNameCavaleiro de Miranda
person.givenNameJoão
person.givenNameSofia Rita
person.givenNameNuno
person.givenNamePaula
person.givenNamePedro Michael
person.identifierhttps://scholar.google.com/citations?user=qEjuc1sAAAAJ&hl=en
person.identifier452149
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person.identifier.orcid0000-0002-6920-7152
person.identifier.orcid0000-0002-0576-8364
person.identifier.orcid0000-0002-5016-0868
person.identifier.orcid0000-0003-1474-9496
person.identifier.orcid0000-0002-6793-8111
person.identifier.ridN-4073-2013
person.identifier.scopus-author-id57192920949
person.identifier.scopus-author-id7006403383
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project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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