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Advances in phytochemical delivery systems for improved anticancer activity

2020-01Journal article Open access
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datacite.subject.fosCiências Médicas::Biotecnologia Médica
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLagoa, Ricardo
dc.contributor.authorSilva, João
dc.contributor.authorRodrigues, Joaquim Rui
dc.contributor.authorBishayee, Anupam
dc.date.accessioned2025-10-22T15:32:35Z
dc.date.available2025-10-22T15:32:35Z
dc.date.issued2020-01
dc.description.abstractNatural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, resveratrol, celastrol, curcumin, berberine and camptothecins, carried by liposomes, nanoparticles, nanoemulsions and films showed promising results. Strategies to avoid drug metabolism, overcome physiological barriers and achieve higher concentration at cancer sites through skin, buccal, nasal, vaginal, pulmonary and colon targeted delivery are presented. Current limitations, challenges and future research directions are also discussed.eng
dc.description.sponsorshipR.L. and J.R.R. acknowledge the support by “Fundação para a Ciência e Tecnologia” (FCT – Portugal), through the research project PTDC/BIA-MIB/31864/2017.
dc.identifier.citationRicardo Lagoa, João Silva, Joaquim Rui Rodrigues, Anupam Bishayee, Advances in phytochemical delivery systems for improved anticancer activity, Biotechnology Advances, Volume 38, 2020, 107382, ISSN 0734-9750, https://doi.org/10.1016/j.biotechadv.2019.04.004.
dc.identifier.doi10.1016/j.biotechadv.2019.04.004
dc.identifier.eissn1873-1899
dc.identifier.issn0734-9750
dc.identifier.urihttp://hdl.handle.net/10400.8/14357
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0734975019300631?via%3Dihub#ab0005
dc.relation.ispartofBiotechnology Advances
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCancer
dc.subjectChemoprevention
dc.subjectTherapy
dc.subjectNanoparticles
dc.subjectLiposomes
dc.subjectDrug release
dc.subjectPhytochemicals
dc.subjectCurcumin
dc.subjectEpigallocatechin-3-gallate
dc.subjectClinical trials
dc.titleAdvances in phytochemical delivery systems for improved anticancer activityeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIB%2F31864%2F2017/PT
oaire.citation.endPage22
oaire.citation.startPage1
oaire.citation.titleBiotechnology Advances
oaire.citation.volume38
oaire.fundingStream3599-PPCDT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLagoa
person.familyNameSilva
person.familyNameRodrigues
person.givenNameRicardo
person.givenNameJoão
person.givenNameJoaquim Rui
person.identifier124357
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person.identifier.ciencia-id9819-5C0E-48C2
person.identifier.ciencia-id9018-0B83-E2C6
person.identifier.orcid0000-0003-2375-6612
person.identifier.orcid0000-0002-6139-6841
person.identifier.orcid0000-0002-9756-1124
person.identifier.ridL-4137-2014
person.identifier.scopus-author-id23051352300
person.identifier.scopus-author-id10242931100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, resveratrol, celastrol, curcumin, berberine and camptothecins, carried by liposomes, nanoparticles, nanoemulsions and films showed promising results. Strategies to avoid drug metabolism, overcome physiological barriers and achieve higher concentration at cancer sites through skin, buccal, nasal, vaginal, pulmonary and colon targeted delivery are presented. Current limitations, challenges and future research directions are also discussed.
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