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High cytotoxicity and anti-proliferative activity of algae extracts on an in vitro model of human hepatocellular carcinoma

2016-08-12Journal article Open access
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datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg14:Proteger a Vida Marinha
dc.contributor.authorAlves, Celso
dc.contributor.authorPinteus, Susete
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2025-05-28T11:43:42Z
dc.date.available2025-05-28T11:43:42Z
dc.date.issued2016-08-12
dc.description.abstractBackground Cancer represents a serious threat for human health with high social and economic impacts worldwide. Therefore, the development of new anticancer drugs is of most importance. The aim of the present study was to evaluate the antitumor potential of twelve algae from Portugal coast on an in vitro model of human hepatocellular carcinoma (HepG-2 cells). Results Both extracts of Asparagopsis armata (1000 µg/ml; 24 h) presented high cytotoxicity with 11.22 ± 2.98 and 1.51 ± 0.38 % of HepG-2 live cells, respectively. Sphaerococcus coronopifolius methanolic and dichloromethane extracts (1000 µg/ml) also generated high reduction on HepG-2 viability (14.04 ± 2.62 and 12.84 ± 3.82 % of HepG-2 live cells, respectively). The most potent anti-proliferative activity was induced by dichloromethane extract (1000 µg/ml; 24 h) of Sphaerococcus coronopifolius, Asparagopsis armata and Plocamium cartilagineum with 99.61 ± 0.27, 98.56 ± 0.81 and 85.13 ± 1.04 % of cell’s proliferation reduction, respectively. Sphaerococcus coronopifolius dichloromethane extract exhibited the highest potency both on cytotoxicity and anti-proliferation assays with an IC50 of 14.1 and 32.3 μg/ml, respectively. Conclusions Sphaerococcus coronopifolius is a promising source of new molecules with possible application on cancer therapeutics.por
dc.description.sponsorshipThis study had the support of the Fundação para a Ciência e a Tecnologia (FCT) through Red2Discovery Project (PTDC/MAR-BIO/6149/2014), co-financed by COMPETE (POCI-01-0145-FEDER-016791), and Strategic Project UID/MAR/04292/2013 granted to MARE and the support of the FP7 EU project ‘BAMMBO: Sustainable production of Biologically Active Molecules of Marine Based Origin’ (FP7 n 265896/http// www.bammbo.eu). C.A. and S.P. are financial supported by a grant from FCT—Fundação para a Ciência e Tecnologia (SFRH/BD/97764/2013 and SFRH/BD/96203/2013, respectively).
dc.identifier.citationAlves, C., Pinteus, S., Horta, A. et al. High cytotoxicity and anti-proliferative activity of algae extracts on an in vitro model of human hepatocellular carcinoma. SpringerPlus 5, 1339 (2016). https://doi.org/10.1186/s40064-016-2938-2
dc.identifier.doi10.1186/s40064-016-2938-2
dc.identifier.issn2193-1801
dc.identifier.urihttp://hdl.handle.net/10400.8/13014
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Science and Business Media LLC
dc.relationMARE - Marine and Environmental Sciences Centre
dc.relationSPHAEROCOCCUS CORONOPIFOLIUS BROMOTERPENES: ANTITUMOR ACTIVITY AND INTRACELLULAR SIGNAL PATHWAYS CHARACTERIZATION ON IN VITRO HUMAN CELLULAR CANCER MODELS
dc.relationADD VALUE TO THE MARINE INVADERS ASPARAGOPSIS ARMATA AND SARGASSUM MUTICUM
dc.relation.hasversionhttps://springerplus.springeropen.com/articles/10.1186/s40064-016-2938-2
dc.relation.ispartofSpringerPlus
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBioactive compounds
dc.subjectMarine natural products
dc.subjectHepG-2 cells
dc.subjectSeaweeds
dc.subjectAntitumor activity
dc.subjectCancer
dc.titleHigh cytotoxicity and anti-proliferative activity of algae extracts on an in vitro model of human hepatocellular carcinomaeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMARE - Marine and Environmental Sciences Centre
oaire.awardTitleSPHAEROCOCCUS CORONOPIFOLIUS BROMOTERPENES: ANTITUMOR ACTIVITY AND INTRACELLULAR SIGNAL PATHWAYS CHARACTERIZATION ON IN VITRO HUMAN CELLULAR CANCER MODELS
oaire.awardTitleADD VALUE TO THE MARINE INVADERS ASPARAGOPSIS ARMATA AND SARGASSUM MUTICUM
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMAR-BIO%2F6149%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F97764%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F96203%2F2013/PT
oaire.citation.issue1
oaire.citation.titleSpringerPlus
oaire.citation.volume5
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamFARH
oaire.fundingStreamFARH
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAlves
person.familyNamePinteus
person.familyNamePedrosa
person.givenNameCelso
person.givenNameSusete
person.givenNameRui
person.identifier159091
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person.identifier.ciencia-id661E-9677-74C5
person.identifier.ciencia-id3817-33DE-919E
person.identifier.orcid0000-0003-1581-2127
person.identifier.orcid0000-0002-3290-3111
person.identifier.orcid0000-0003-0970-0575
person.identifier.ridB-4815-2015
person.identifier.scopus-author-id55654969100
person.identifier.scopus-author-id55655328300
person.identifier.scopus-author-id7005010300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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