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Evaluation of in vitro degradation of PCL scaffolds fabricated via BioExtrusion. Part 1: Influence of the degradation environment

2010-06Journal article Open access
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datacite.subject.fosCiências Naturais::Matemáticas
datacite.subject.fosCiências Naturais::Ciências da Computação e da Informação
datacite.subject.fosEngenharia e Tecnologia::Outras Engenharias e Tecnologias
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorDomingos, M.
dc.contributor.authorChiellini, F.
dc.contributor.authorCometa, S.
dc.contributor.authorDe Giglio, E.
dc.contributor.authorGrillo-Fernandes, E.
dc.contributor.authorBártolo, P.
dc.contributor.authorChiellini, E.
dc.date.accessioned2025-11-12T17:23:59Z
dc.date.available2025-11-12T17:23:59Z
dc.date.issued2010-06
dc.descriptionFonte: https://www.researchgate.net/publication/233350329_Evaluation_of_in_vitro_degradation_of_PCL_scaffolds_fabricated_via_BioExtrusion_Part_1_Influence_of_the_degradation_environment
dc.description.abstractOne of the most promising approaches in tissue engineering (TE) comprises the development of 3D porous scaffolds which are able to promote tissue regeneration. Biocompatible and biodegradable poly(e-caprolactone) (PCL) structures are increasingly used as temporary extra-cellular matrices for bone tissue engineering. To ensure an appropriate bone restoration over the long term, the selected material must have a degradation rate that match the in-growth of new bone. The in vivo process, by which the scaffold degrades and is resorbed transferring the load and function back to the host tissue, is complex. Consequently, an appropriate preliminary in vitro study is required. A novel extrusion-based technology called BioExtruder was used to produce PCL porous scaffolds made with layers of directionally aligned microfilaments. The in vitro degradation behaviour in both simulated body fluid (SBF) and phosphate buffer solution (PBS) were investigated over 6 months. The characterization of the degradation behaviour of the structures was performed at specific times by evaluating changes in the average molecular weight, the weight loss and its thermal properties. Morphological and surface chemical analyses were also performed using a Scanning Electron Microscopy (SEM) and an X-ray Photoelectron Spectroscopy (XPS), respectively.eng
dc.description.sponsorshipThis work was performed within the framework of the European Network of Excellence ‘‘EXPERTISSUES’’ (Project NMP3-CT-2004-500283), with the partial financial support by Project PRIN-2006-prot. 2006038548. The authors wish to thank Mr Piero Narducci for recording SEM images of scaffolds.
dc.identifier.citationDomingos, M., Chiellini, F., Cometa, S., De Giglio, E., Grillo-Fernandes, E., Bártolo, P., & Chiellini, E. (2010). Evaluation of in vitro degradation of PCL scaffolds fabricated via BioExtrusion. Part 1: Influence of the degradation environment. Virtual and Physical Prototyping, 5(2), 65–73. https://doi.org/10.1080/17452751003769440.
dc.identifier.doi10.1080/17452751003769440
dc.identifier.eissn1745-2767
dc.identifier.issn1745-2759
dc.identifier.urihttp://hdl.handle.net/10400.8/14597
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor and Francis
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.1080/17452751003769440
dc.relation.ispartofVirtual and Physical Prototyping
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectin vitro degradation
dc.subjectPCL scaffolds
dc.subjectbioextrusion
dc.subjectdegradation environment
dc.titleEvaluation of in vitro degradation of PCL scaffolds fabricated via BioExtrusion. Part 1: Influence of the degradation environmenteng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage73
oaire.citation.issue2
oaire.citation.startPage65
oaire.citation.titleVirtual and Physical Prototyping
oaire.citation.volume5
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDomingos
person.familyNameBartolo
person.givenNameMarco
person.givenNamePaulo
person.identifier203086
person.identifier.ciencia-idB512-2D06-5897
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-6693-790X
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id6603353041
relation.isAuthorOfPublication1fb3bd4b-f499-4db6-93c1-3a671f116d07
relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
relation.isAuthorOfPublication.latestForDiscovery1fb3bd4b-f499-4db6-93c1-3a671f116d07

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One of the most promising approaches in tissue engineering (TE) comprises the development of 3D porous scaffolds which are able to promote tissue regeneration. Biocompatible and biodegradable poly(e-caprolactone) (PCL) structures are increasingly used as temporary extra-cellular matrices for bone tissue engineering. To ensure an appropriate bone restoration over the long term, the selected material must have a degradation rate that match the in-growth of new bone. The in vivo process, by which the scaffold degrades and is resorbed transferring the load and function back to the host tissue, is complex. Consequently, an appropriate preliminary in vitro study is required. A novel extrusion-based technology called BioExtruder was used to produce PCL porous scaffolds made with layers of directionally aligned microfilaments. The in vitro degradation behaviour in both simulated body fluid (SBF) and phosphate buffer solution (PBS) were investigated over 6 months. The characterization of the degradation behaviour of the structures was performed at specific times by evaluating changes in the average molecular weight, the weight loss and its thermal properties. Morphological and surface chemical analyses were also performed using a Scanning Electron Microscopy (SEM) and an X-ray Photoelectron Spectroscopy (XPS), respectively.
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