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Towards the Development of Delivery Systems of Bioactive Compounds With Eyes Set on Pharmacokinetics

2021-02-06Book part Open access
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dc.contributor.authorSilva, João S.
dc.contributor.authorMarques-da-Silva, Dorinda
dc.contributor.authorLagoa, Ricardo
dc.date.accessioned2021-06-22T09:53:04Z
dc.date.available2022-02-06T01:30:10Z
dc.date.issued2021-02-06
dc.description.abstractDelivery systems carrying natural bioactive compounds for enhanced targeting and controlled release are capturing increasing attention. High loadings and sustained release are common design goals. However, in the case of compounds naturally present in human nutrition and physiology, further efforts are justified to optimize their bioactivity and promote clinical success. In this work, it is proposed a specific attention to the regulation of drug temporal presentation as important factor to obtain novel multifunctional delivery systems meeting higher therapeutic efficiencies. Case studies on the relation between drug release dynamics and biological responses are presented for some major delivery strategies and different bioactive molecules. Pharmacokinetic essential concepts and issues concerning the multi-target mode of action typical of the pharmacological properties of natural compounds are discussed in the perspective of improving the development of efficient drug formulations. Several classes of controlled release systems are considered through the chapter, and laboratory setups for testing films and particulate delivery systems are detailed, as well as the application of models for kinetic analysis. Descriptions are illustrated with experimental results obtained with caffeine and epicatechin in our laboratory. Future investigations will benefit from preclinical and clinical evaluation of the new formulations developed by emerging approaches and tools that are being suggested by diverse authors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJoão S. Silva, Dorinda Marques-da-Silva, Ricardo Lagoa, Chapter 8 - Towards the Development of Delivery Systems of Bioactive Compounds With Eyes Set on Pharmacokinetics, Editor(s): Ahmad Taher Azar, Modeling and Control of Drug Delivery Systems, Academic Press, 2021, Pages 125-144, ISBN 9780128211854, https://doi.org/10.1016/B978-0-12-821185-4.00006-3pt_PT
dc.identifier.doihttps://doi.org/10.1016/B978-0-12-821185-4.00006-3pt_PT
dc.identifier.isbn978-0-12-821185-4
dc.identifier.urihttp://hdl.handle.net/10400.8/5844
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAcademic Presspt_PT
dc.relationMBStox (PTDC/BIA-MIB/31864/2017), Fundação para a Ciência e Tecnologiapt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/B978-0-12-821185-4.00006-3pt_PT
dc.subjectCompartmental modelspt_PT
dc.subjectControlled releasept_PT
dc.subjectDermal deliverypt_PT
dc.subjectDrug absorptionpt_PT
dc.subjectFranz cellspt_PT
dc.subjectPhytochemicalspt_PT
dc.subjectResearch Subject Categories::TECHNOLOGY::Bioengineeringpt_PT
dc.subjectResearch Subject Categories::MEDICINEpt_PT
dc.titleTowards the Development of Delivery Systems of Bioactive Compounds With Eyes Set on Pharmacokineticspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage144pt_PT
oaire.citation.startPage125pt_PT
oaire.citation.titleModeling and Control of Drug Delivery Systemspt_PT
person.familyNameSilva
person.familyNameLagoa
person.givenNameJoão
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id9819-5C0E-48C2
person.identifier.ciencia-id521A-35C1-078D
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0002-6139-6841
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id35751117400
person.identifier.scopus-author-id23051352300
rcaap.rightsopenAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublicationca7fce54-bbbc-40e8-8816-4b676f3a7c91
relation.isAuthorOfPublication20daf20e-f1d3-455c-a6fd-e10754cca411
relation.isAuthorOfPublication8a139213-9a89-4bd3-93ee-1e332519f96b
relation.isAuthorOfPublication.latestForDiscovery20daf20e-f1d3-455c-a6fd-e10754cca411

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