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3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold properties

2022Journal article Open access
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dc.contributor.authorBiscaia, Sara
dc.contributor.authorBranquinho, Mariana V.
dc.contributor.authorAlvites, Rui D.
dc.contributor.authorFonseca, Rita
dc.contributor.authorSousa, Ana Catarina
dc.contributor.authorPedrosa, Sílvia Santos
dc.contributor.authorCaseiro, Ana R.
dc.contributor.authorGuedes, Fernando
dc.contributor.authorPatrício, Tatiana
dc.contributor.authorViana, Tânia
dc.contributor.authorMateus, Artur
dc.contributor.authorMaurício, Ana C.
dc.contributor.authorAlves, Nuno
dc.date.accessioned2023-04-12T12:53:57Z
dc.date.available2023-04-12T12:53:57Z
dc.date.issued2022
dc.descriptionThis work was developed within the scope of the project insitu.Biomas—Reinvent biomanufacturing systems by using an usability approach for in situ clinic temporary implants fabrication, with the reference POCI-01-0247-FEDER-017771 from the Portuguese National Innovation Agency, and supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the following Projects: UIDB/04044/2020, UIDP/04044/2020, PEst-OE/AGR/UI0211/2011 and PAMI—ROTEIRO/0328/2013 (Nº 022158). Mariana Vieira Branquinho (SFRH/BD/146172/2019), Ana Catarina Sousa SFRH/BD/146689/2019) and Rui Damásio Alvites (SFRH/BD/116118/2016), acknowledge the FCT for financial support.pt_PT
dc.description.abstractBone tissue engineering has been developed in the past decades, with the engineering of bone substitutes on the vanguard of this regenerative approach. Polycaprolactone-based scaffolds are fairly applied for bone regeneration, and several composites have been incorporated so as to improve the scaffolds’ mechanical properties and tissue in-growth. In this study, hydroxyapatite is incorporated on polycaprolactone-based scaffolds at two different proportions, 80:20 and 60:40. Scaffolds are produced with two different blending methods, solvent casting and melt blending. The prepared composites are 3D printed through an extrusion-based technique and further investigated with regard to their chemical, thermal, morphological, and mechanical characteristics. In vitro cytocompatibility and osteogenic differentiation was also assessed with human dental pulp stem/stromal cells. The results show the melt-blending-derived scaffolds to present more promising mechanical properties, along with the incorporation of hydroxyapatite. The latter is also related to an increase in osteogenic activity and promotion. Overall, this study suggests polycaprolactone/hydroxyapatite scaffolds to be promising candidates for bone tissue engineering, particularly when produced by the MB method.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBiscaia, S.; Branquinho, M.V.; Alvites, R.D.; Fonseca, R.; Sousa, A.C.; Pedrosa, S.S.; Caseiro, A.R.; Guedes, F.; Patrício, T.; Viana, T.; et al. 3D Printed Poly(#-caprolactone)/ Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on a Composite Preparation by Melt Blending or Solvent Casting Techniques and the Influence of Bioceramic Content on Scaffold Properties. Int. J. Mol. Sci. 2022, 23, 2318. https://doi.org/10.3390/ ijms23042318pt_PT
dc.identifier.doi10.3390/ ijms23042318pt_PT
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.8/8363
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationStrategic Project - UI 211 - 2011-2012
dc.relationRegenerative therapies applying synovial membrane-derived mesenchymal stem cells targeting the musculoskeletal system
dc.relationAssociation of 3D printing and cellular therapies for regenerative medicine
dc.relationCombined use of olfactory mucosa mesenchymal stem cells and biomaterials in regenerative therapies after peripheral nerve injury
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/4/2318pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolycaprolactonept_PT
dc.subjectHydroxyapatitept_PT
dc.subjectCompositespt_PT
dc.subjectSolvent castingpt_PT
dc.subjectMelt blendingpt_PT
dc.subject3D printingpt_PT
dc.subjectCytocompatibilitypt_PT
dc.subjectBone tissue engineeringpt_PT
dc.title3D printed poly(E-caprolactone)/Hydroxyapatite scaffolds for bone tissue engineering: A comparative study on a Composite Preparation by Melt blending or solvent casting techniques and the influence of bioceramic content on scaffold propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleStrategic Project - UI 211 - 2011-2012
oaire.awardTitleRegenerative therapies applying synovial membrane-derived mesenchymal stem cells targeting the musculoskeletal system
oaire.awardTitleAssociation of 3D printing and cellular therapies for regenerative medicine
oaire.awardTitleCombined use of olfactory mucosa mesenchymal stem cells and biomaterials in regenerative therapies after peripheral nerve injury
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0211%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F146172%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146689%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F116118%2F2016/PT
oaire.citation.issue4pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume23pt_PT
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oaire.fundingStream6817 - DCRRNI ID
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