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Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells

2020Journal article Restricted access
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dc.contributor.authorBeeby, Ellie
dc.contributor.authorMagalhães, Mariana
dc.contributor.authorPoças, Juliana
dc.contributor.authorCollins, Thomas
dc.contributor.authorLemos, Marco F.L.
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCabral, Célia
dc.contributor.authorPires, Isabel M.
dc.date.accessioned2021-07-23T14:37:25Z
dc.date.available2021-07-23T14:37:25Z
dc.date.issued2020
dc.descriptionAcknowledgments : We would like to thank the support provided by the following funders: Higher Education Funding Council for England (HEFCE) through the University of Hull, U.K.; Foundation for Science and Technology (FCT, Portugal), through the Strategic Projects: UID/MAR/04292/2019 (MARE), UID/NEU/04539/2013 and UID/NEU/04539/2019 (CNC.IBILI), UIDB/04539/2020 and UIDP/04539/2020 (CIBB); Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019); Foundation for Science and Technology (FCT, Portugal) project POINT4PAC (SAICTPAC/0019/2015-LISBOA-01-0145-FEDER-016405); EASME Blue Labs project AMALIA (EASME/EMFF/2016/1.2.1.4/03/SI2.750419), European Union; Integrated Programme of SR&TD “SmartBioR” (reference Centro-01-0145-FEDER000018), co-funded by Centro (2020) program, Portugal 2020, European Union, through the European Regional Development Fund.
dc.description.abstractEthnopharmacological relevance: Despite advances in modern therapeutic strategies, cancer remains the second leading cause of death worldwide. Therefore, there is a constant need to develop more efficient anticancer targeting strategies. The anticancer therapeutic proprieties of medicinal plants and their bioactive compounds have been reported for several years, making natural extracts and/or compounds derived from these a promising source of novel anticancer agents. Sand dune plants are subjected to severe environmental stresses, leading to the development of adaptations, including the production of secondary metabolites with a wide range of bioactivities, such as: anti-inflammatory, analgesic, antiseptic, hypoglycaemic, hypotensive, antinociceptive, antioxidant and anticancer. Aim of the study: The anticancer potential of sand dune plants remains under-investigated, so this research describes the characterisation of the composition of bioactive EOs from sand-dune plants of Peniche (Portugal), and assessment of their activity in vitro and potential mechanism of action. Materials and methods: EOs were extracted from six sand-dune species of plants from Peniche sand dunes: Crithmum maritimum L., Seseli tortuosum L., Artemisia campestris subsp. maritima (DC.) Arcang., Juniperus phoenicea var. turbinata (Guss.) Parl., Otanthus maritimus (L.) Hoffmanns. & Link, and Eryngium maritimum L.. EOs composition was fully characterised chemically using Gas Chromatography-Mass Spectrometry (GC-MS). The assessment of anticancer activity and mechanism of action was performed in vitro using breast and colorectal cancer 2D and 3D spheroid cell line models, through cell proliferation assay, western blotting analysis, and cell cycle analysis. Results: EOs from the majority of the species tested (S. tortuosum, A. campestris subsp. maritima, O. maritimus, and E. maritimum) were mainly composed by hydrocarbon compounds (sequisterpenes and monoterpenes), showing antiproliferative activity in both 2D and 3D models. EO extracted from S. tortuosum and O. maritimus were identified as having the lowest IC50 values for both cell lines when compared with the other species tested. Furthermore, this antiproliferative activity was associated with increased p21 expression and induction of apoptosis. Conclusions: The present study suggests that EOs extracted from S. tortuosum and O. maritimus present promising cytotoxic properties. Further evaluation of the extracts and their key components as potential anticancer agents should therefore be explored.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBeeby, E., Magalhães, M., Poças, J., Collins; T., Lemos, M.F.L., Barros, L., Ferreira, I.C.F.R., Cabral, C. & Pires, I.M. (2020). Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells. Journal of Ethnopharmacology, 258. https://doi.org/10.1016/j.jep.2020.112803pt_PT
dc.identifier.doi10.1016/j.jep.2020.112803pt_PT
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/10400.8/5932
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMARE - Marine and Environmental Sciences Centre
dc.relationCNC. IBILI
dc.relationCNC. IBILI
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.relationMountain Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSand-dune plantspt_PT
dc.subjectEssential oilspt_PT
dc.subjectNatural productspt_PT
dc.subjectAntitumoral propertiespt_PT
dc.titleSecondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMARE - Marine and Environmental Sciences Centre
oaire.awardTitleCNC. IBILI
oaire.awardTitleCNC. IBILI
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardTitleMountain Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMAR%2F04292%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FNEU%2F04539%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FNEU%2F04539%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04539%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04539%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2019/PT
oaire.citation.titleJournal of Ethnopharmacologypt_PT
oaire.citation.volume258pt_PT
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePoças Almeida
person.familyNameLemos
person.givenNameJuliana
person.givenNameMarco
person.identifier996337
person.identifier.orcid0000-0003-2877-473X
person.identifier.orcid0000-0001-9887-1864
person.identifier.ridF-7951-2011
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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