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Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties

2019Journal article Open access
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dc.contributor.authorCosta, M.M.
dc.contributor.authorLima, R.
dc.contributor.authorMelo-Fonseca, F.
dc.contributor.authorBartolomeu, F.
dc.contributor.authorAlves, N.
dc.contributor.authorMiranda, A.
dc.contributor.authorGasik, M.
dc.contributor.authorSilva, F.S.
dc.contributor.authorSilva, N.A.
dc.contributor.authorMiranda, G.
dc.date.accessioned2023-05-31T14:58:25Z
dc.date.available2023-05-31T14:58:25Z
dc.date.issued2019
dc.descriptionAcknowledgments This work was supported by FCT (Fundação para a Ciência e Tecnologia) through the grants SFRH/BD/140191/2018; SFRH/BPD/112111/2015, SFRH/BD/128657/2017, SFRH/BD/141056/2018; SFRH/BPD/97701/2013, PD/BDE/127836/2016, and the projects PTDC/EMS-TEC/5422/2014_ADAPTPROSTHESIS and NORTE-01- 0145-FEDER-000018-HAMaBICo. Additionally, this work was supported by FCT with the reference project UID/EEA/04436/2013, by FEDER funds through the COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI-01-0145-FEDER-006941.pt_PT
dc.description.abstractLoad-bearing implants success is strongly dependent on several physical and chemical properties that are known to drive cellular response. In this work, multi-material β-TCP-Ti6Al4V cellular structures were designed to combine Ti6Al4V mechanical properties and β-Tricalcium Phosphate bioactivity, in order to promote bone ingrowth as the bioactive material is being absorbed and replaced by newly formed bone. In this sense, the produced structures were characterized regarding roughness, wettability, β-TCP quantity and quality inside the structures after fabrication and the pH measured during cell culture (as consequence of β-TCP dissolution) and those aspects were correlated with cellular viability, distribution, morphology and proliferation. These structures displayed a hydrophilic behavior and results showed that the addition of β-TCP to these cellular structures led to an alkalization of the medium, aspect that significantly influences the cellular response. Higher impregnation ratios were found more adequate for lowering the media pH and toxicity, and thus enhance cell adhesion and proliferation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationM.M. Costa, R. Lima, F. Melo-Fonseca, F. Bartolomeu, N. Alves, A. Miranda, M. Gasik, F.S. Silva, N.A. Silva, G. Miranda, Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties, Materials Science and Engineering: C, Volume 98, 2019, Pages 705-716, ISSN 0928-4931, https://doi.org/10.1016/j.msec.2019.01.016.pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.msec.2019.01.016pt_PT
dc.identifier.eissn1873-0191
dc.identifier.issn0928-4931
dc.identifier.urihttp://hdl.handle.net/10400.8/8551
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPTDC/EMS-TEC/5422/2014_ADAPTPROSTHESISpt_PT
dc.relationalterado para: “Multi-Functional Multi-Material Structures for Orthopedic Implants using Laser-Assisted Strategies” Smart Bioactive Structures for Implants for Life
dc.relationDevelopment of Multi-Functional Structures by Multi-Material Selective Laser Melting/Sintering
dc.relationSmart design of Titanium/NiTi cellular structured implants by Multi-Material-Selective-Laser-Melting
dc.relationDesign of bone-stimulating implants by mechanotransduction modulation
dc.relationA POLY-PHARMACOLOGICAL THERAPY TO REPAIR THE INJURED SPINAL CORD. IS IT THE WHOLE GREATER THAN THE SUM OF ITS PARTS
dc.relationA Poly-Pahrmacological Therapy to Repair the Injured Spinal Cord
dc.relationMicroelectromechanical Systems Research Unit
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0928493118318307?casa_token=TJ9MUB4790sAAAAA:-1hE2bn1E8Wd4K8SDqFA21odNF24vKS49KKBcI7ElobxorsLVjSiHN5UOof4Mil4U-HPAFnspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMulti-material cellular structurespt_PT
dc.subjectSelective Laser Meltingpt_PT
dc.subjectPress and Sinteringpt_PT
dc.subjectTi6Al4Vpt_PT
dc.subjectβ-Tricalcium Phosphatept_PT
dc.titleDevelopment of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical propertiespt_PT
dc.typejournal article
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oaire.awardTitlealterado para: “Multi-Functional Multi-Material Structures for Orthopedic Implants using Laser-Assisted Strategies” Smart Bioactive Structures for Implants for Life
oaire.awardTitleDevelopment of Multi-Functional Structures by Multi-Material Selective Laser Melting/Sintering
oaire.awardTitleSmart design of Titanium/NiTi cellular structured implants by Multi-Material-Selective-Laser-Melting
oaire.awardTitleDesign of bone-stimulating implants by mechanotransduction modulation
oaire.awardTitleA POLY-PHARMACOLOGICAL THERAPY TO REPAIR THE INJURED SPINAL CORD. IS IT THE WHOLE GREATER THAN THE SUM OF ITS PARTS
oaire.awardTitleA Poly-Pahrmacological Therapy to Repair the Injured Spinal Cord
oaire.awardTitleMicroelectromechanical Systems Research Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F140191%2F2018/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F97701%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBDE%2F127836%2F2016/PT
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oaire.citation.endPage716pt_PT
oaire.citation.startPage705pt_PT
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume98pt_PT
oaire.fundingStreamPOR_NORTE
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oaire.fundingStream6817 - DCRRNI ID
person.familyNameAlves
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